Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2
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Summary
Experimental evidence of an important role for ACE2 in limiting abdominal aortic aneurysm development and growth is provided and resveratrol upregulated ACE2 and inhibited AAA growth in a mouse model.
- Type
- article
- Published
- 2017-09-22
- Cited by
- 70
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W2757846252
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41794086
Keywords
Resveratrol, Angiotensin II, Downregulation and upregulation, Endocrinology, Sirtuin 1
References
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- Smooth muscle phenotypic modulation is an early event in aortic aneurysms
- Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases.
- Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
- Urocortin 2 is associated with abdominal aortic aneurysm and mediates anti-proliferative effects on vascular smooth muscle cells via corticotrophin releasing factor receptor 2.
- Cross talk between angiotensin-(1-7)/Mas axis and sirtuins in adipose tissue and metabolism of high-fat feed mice.
- Notch γ-Secretase Inhibitor Dibenzazepine Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE Knockout Mice by Multiple Mechanisms
- Resveratrol protects vascular smooth muscle cells against high glucose-induced oxidative stress and cell proliferation in vitro
- The ACE2 gene: its potential as a functional candidate for cardiovascular disease.
- ACE2, a new regulator of the renin–angiotensin system
- SIRT1: role in cardiovascular biology.
- Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress.
- Phosphorylation of AKT and abdominal aortic aneurysm formation.
- Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease
- Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery.
Cited by
- Dual-Targeted Theranostic Delivery of miRs Arrests Abdominal Aortic Aneurysm Development
- Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm
- The Renin-Angiotensin System and Cardiovascular Functions
- Recent Highlights of ATVB: Reporting Sex and Sex Differences in Preclinical Studies
- Abdominal aortic aneurysm: update on pathogenesis and medical treatments
- Recent Highlights of ATVB Updates of Recent Aortic Aneurysm Research
- The Potential Beneficial Effects of Resveratrol on Cardiovascular Complications in Marfan Syndrome Patients–Insights from Rodent-Based Animal Studies
- One amino acid change of Angiotensin II diminishes its effects on abdominal aortic aneurysm
- Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-β1 in alveolar epithelial cells.
- The association between copy number variant of Angiotensin Converting Enzyme gene and the risk of Ascending Aortic Aneurysm in Bicuspid and Tricuspid Aortic Valve
- Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation
- Resveratrol ameliorates the cyclosporine-induced vascular and renal impairments: possible impact of the modulation of renin-angiotensin system.
- Hypercholesterolemia Accelerates Both the Initiation and Progression of Angiotensin II-induced Abdominal Aortic Aneurysms
- Association of impaired arterial wall properties with the presence of coronary artery disease in patients with abdominal aortic aneurysms
- MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1.
- MMPs and ADAMs/ADAMTS Inhibition Therapy of Abdominal Aortic Aneurysm
- Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms
- Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity
- Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice.
- Physiological cyclic stretch up-regulates angiotensin-converting enzyme 2 expression to reduce proliferation and migration of vascular smooth muscle cells
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