Angiotensin-converting enzyme 2 protects from severe acute lung failure
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Summary
It is reported that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year.
- Type
- article
- Published
- 2005-07-07
- Cited by
- 2,419
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964982019
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4303775
Keywords
ARDS, Angiotensin-converting enzyme 2, Medicine, Angiotensin II, Renin–angiotensin system
References
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- PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
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- Epidemiology and outcome of acute respiratory failure in intensive care unit patients
- Angiotensin II Type 1a Receptor-deficient Mice with Hypotension and Hyperreninemia (*)
- Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome.
- Cloning, expression and regulation of angiotensin II receptors.
- Identification of severe acute respiratory syndrome in Canada.
- A novel coronavirus associated with severe acute respiratory syndrome.
- Tissue-specific expression of type 1 angiotensin II receptor subtypes. An in situ hybridization study.
- A cluster of cases of severe acute respiratory syndrome in Hong Kong.
- A major outbreak of severe acute respiratory syndrome in Hong Kong.
Cited by
- Coronavirus Pathogenesis
- The severe acute respiratory syndrome (SARS)
- ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR.
- Severe Acute Respiratory Syndrome and Coronavirus
- Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus
- Acute Respiratory Distress Syndrome
- Angiotensin II Use in Refractory Multisystem Shock: A Case Report
- Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective
- Insights from the Association of SARS-CoV S-Protein with its Receptor, ACE2
- Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome
- Therapeutic perspectives of Angiotensin-(1-7) in heart failure
- Síndrome de insuficiencia respiratoria aguda
- Acute Lung Injury and Pulmonary Vascular Permeability: Use of Transgenic Models
- Host Entry Factors for Human Coronaviruses
- New Insights into the Roles of Metalloproteinases in Neurodegeneration and Neuroprotection
- Ventilation‐Induced Lung Injury
- Combination therapy with human umbilical cord mesenchymal stem cells and angiotensin‐converting enzyme 2 is superior for the treatment of acute lung ischemia–reperfusion injury in rats
- Alcoholic Lung Disease
- Residues affecting the chloride regulation and substrate selectivity of the angiotensin‐converting enzymes (ACE and ACE2) identified by site‐directed mutagenesis
- Molecular Pathology of Emerging Coronavirus Infections
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