Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands
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Summary
A unified model for Angiopoietin-induced Tie2 signaling is proposed which highlights the essential role of Tie1 in vascular homeostasis and demonstrates that the Tie1-Tie2 interactions are dynamic, inhibitory, and differentially modulated by Angiopoietin-1 and -2, thereby providing a discrete molecular mechanism for the observed variations in Angiopoietin function.
- Type
- article
- Published
- 2010-03-12
- Cited by
- 187
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2078338839
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6038110
Keywords
Angiopoietin receptor, Biology, Receptor tyrosine kinase, Angiopoietin, Cell biology
References
- Angiopoietin-1 and Angiopoietin-2 Share the Same Binding Domains in the Tie-2 Receptor Involving the First Ig-like Loop and the Epidermal Growth Factor-like Repeats*
- Getting Tie(2)d up in angiogenesis.
- tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.
- Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization.
- The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.
- Vascular-specific growth factors and blood vessel formation
- The endothelial receptor tyrosine kinase tie‐1 is upregulated by hypoxia and vascular endothelial growth factor
- Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
- Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts
- Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis.
- Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
- Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
- Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
- Statistical potential for assessment and prediction of protein structures
- The CCP4 suite: programs for protein crystallography.
- The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.
- Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins
- Imaging biochemistry inside cells.
- TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth.
- Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.
Cited by
- Angiopoietins in angiogenesis.
- Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS
- Signaling Network Map of Endothelial TEK Tyrosine Kinase
- Tie2 regulates endocardial sprouting and myocardial trabeculation.
- The role of Ang/Tie signaling in lymphangiogenesis.
- Developing Somatic Hypermutation as a Protein Engineering Tool to Study Angiopoietin Binding
- PECAM-1 expression by mesenchymal stromal cells is regulated by Notch signalling
- Engineering Novel Angiopoietin Receptor Ligands
- Activités inflammatoires des angiopoïétinessur les neutrophiles
- A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
- Effect of aging and cardiovascular risk factors on receptor Tie1 expression in human erectile tissue.
- Angiopoietins differentially influence in vitro angiogenesis by endothelial cells of different origin
- Notch1 signaling in the hepatic microcirculation and chronic liver disease
- Regulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling Pathways
- Angiopoietin-1 and -2 in Infectious Diseases associated with Endothelial Cell Dysfunction
- Receptor tyrosine kinases and their activation in melanoma
- Real-time PCR study of Ang1, Ang2, Tie-2, VEGF, and KDR expression in human erectile tissue during aging.
- Vascular Growth Factors and Glomerular Disease
- Opposing Effects of the Angiopoietins on the Thrombin-Induced Permeability of Human Pulmonary Microvascular Endothelial Cells
- Expression and Localization of Angiogenic Growth Factors in Developing Porcine Mesonephric Glomeruli
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- Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.
- Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis
- Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
- Identification and characterisation of chicken cDNAs encoding the endothelial cell-specific receptor tyrosine kinase Tie2 and its ligands, the angiopoietins