Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands

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Summary

A unified model for Angiopoietin-induced Tie2 signaling is proposed which highlights the essential role of Tie1 in vascular homeostasis and demonstrates that the Tie1-Tie2 interactions are dynamic, inhibitory, and differentially modulated by Angiopoietin-1 and -2, thereby providing a discrete molecular mechanism for the observed variations in Angiopoietin function.

Type
article
Published
2010-03-12
Cited by
187
References
40
Access
Open access

Keywords

Angiopoietin receptor, Biology, Receptor tyrosine kinase, Angiopoietin, Cell biology

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