Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
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Summary
In vivo analyses of embryos deficient in Tie-2 showed that it is important in angiogen-esis, particularly for vascular network formation in endothelial cells, which contrasts with previous reports on Tie-1 function in vasculogenesis and/or endothelial cell survival.
- Type
- article
- Published
- 1995-07-06
- Cited by
- 1,904
- References
- 29
- OpenAlex
- https://openalex.org/W1996430165
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4353595
Keywords
Vasculogenesis, Angiogenesis, Receptor tyrosine kinase, Cell biology, Biology
References
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Cited by
- Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt
- Cell-derived Microparticles as Part of Multimarker Strategies to Improve Vascular Risk Prediction
- Analysis of embryonic vascular morphogenesis.
- The embryonic origins of human haematopoiesis
- Angiopoietin-1, angiopoietin-2 and Tie-2 in tumour and non-tumour tissues during growth of experimental melanoma
- Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2.
- Endothelial injury and repair in vasculitis of the young
- Potential role of the angiopoietin/tie2 system in ischemia-induced retinal neovascularization.
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- Podocyte expression of hypoxia-inducible factor (HIF)-1 and HIF-2 during glomerular development.
- Angiopoietin‐1 inhibits endothelial permeability, neutrophil adherence and IL‐8 production
- In Vivo Angiogenic Phenotype of Endothelial Cells and Pericytes Induced by Vascular Endothelial Growth Factor-A
- Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications
- Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase.
- Mast cell-derived angiopoietin-1 plays a critical role in the growth of plasma cell tumors.
- Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice.
- Granulocyte-colony stimulating factor augments neovascularization induced by bone marrow transplantation in rat hindlimb ischemia.
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