Opposing chemokine gradients control human thymocyte migration in situ.
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Summary
Findings point to significant interspecies conservation in thymocyte-stroma interactions and provide the first evidence that chemokines not only attract mature thymocytes to the medulla, but also play an active role in retaining DPThymocytes in the cortex prior to positive selection.
- Type
- article
- Published
- 2013-05-01
- Cited by
- 64
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W2078102740
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19145431
Keywords
Thymocyte, Medulla, Cortex (anatomy), Biology, Stroma
References
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- Chemokines, chemokine receptors and small-molecule antagonists: recent developments.
- Thymic microenvironments for T cell differentiation and selection
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- T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
- Mice lacking major histocompatibility complex class I and class II molecules.
- Humanized mice in translational biomedical research
- A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2
Cited by
- Distinct temporal pattern of T cell receptor signals during positive versus negative selection in situ
- Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns
- The role of the thymic medulla in T cell development and tolerance induction
- T-CELL TREATMENTS FOR SOLID AND HEMATOLOGICAL TUMORS
- Impact d’un gain de fonction de Cxcr4 sur le développement et la compartimentalisation périphérique des lymphocytes
- Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition
- The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus
- Typical Neuron Guiding Molecules Constitutively Control Thymus Physiology
- Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells.
- Conserved and divergent aspects of human T-cell development and migration in humanized mice
- Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
- Thymus medulla fosters generation of natural Treg cells, invariant γδ T cells, and invariant NKT cells: What we learn from intrathymic migration
- Dynamic two‐photon imaging of the immune response to Toxoplasma gondii infection
- Tracking migration during human T cell development
- A microfluidic dual gradient generator for conducting cell-based drug combination assays.
- Stable interactions and sustained T cell receptor signaling characterize thymocyte-thymocyte interactions that support negative selectiona
- Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus
- Cellular imaging in rheumatic diseases
- Plxnd1 Expression in Thymocytes Regulates Their Intrathymic Migration While That in Thymic Endothelium Impacts Medullary Topology
- The functional relationship between hematopoietic stem cells and developing T lymphocytes
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