Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.
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Summary
The use of a murine CD4 enhancer is described in the generation of transgenic mice expressing physiologic levels of human CD4, which mediates rescue of the CD4 lineage and restoration of normal helper cell functions in mice whose endogenous CD4 gene is inactivated.
- Type
- article
- Published
- 1993-04-01
- Cited by
- 218
- References
- 2
- Access
- Open access
- OpenAlex
- https://openalex.org/W1945938648
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28471403
Keywords
Expression (computer science), Gerontology, Library science, Environmental ethics, Biology
References
- Teratocarcinomas and embryonic stem cells : a practical approach
- Studies on the induction and expression of T cell-mediated immunity. X. Inhibition by Lyt 2,3 antisera of cytotoxic T lymphocyte-mediated antigen-specific and -nonspecific cytotoxicity: evidence for the blocking of the binding between T lymphocytes and target cells and not the post-binding cytolytic steps.
Cited by
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- Human CD4 residue Phe 43 is critical for repertoire development and maturation of MHC class II restricted CD4 single‐positive T lineage cells in vivo
- A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
- Inhibition of contact sensitivity in human CD4+ transgenic mice by human CD4‐specific monoclonal antibodies: CD4+ T‐cell depletion is not required
- In vivo receptor‐mediated delivery of a recombinant invasive bacterial toxoid to CD11c+CD8α–CD11bhigh dendritic cells
- Relief of Preintegration Inhibition and Characterization of Additional Blocks for HIV Replication in Primary Mouse T Cells
- The development of an effective vaccine against Chlamydia : utilisation of a non-toxic mucosal adjuvant to generate a protective mucosal response
- The regulation and function of the CD4 coreceptor during T lymphocyte development.
- HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
- Epigenetic Regulation of Lymphocyte Development
- The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression.
- Characterization of Molecular Correlates of the Chronic Humoral Immune Response: Clues towards Eliciting Broadly Neutralizing Antibodies against HIV
- Decellularized amniotic membrane attenuates postinfarct left ventricular remodeling.
- CD4 T cell immunodominance: Studies on the impact of major histocompatibility class II isotypes and DM
- Exploring the pathogenesis of rheumatoid arthritis in transgenic and mutant mice.
- Resistance to Celiac Disease in Humanized HLA-DR3-DQ2-Transgenic Mice Expressing Specific Anti-Gliadin CD4+ T Cells1
- CD4 Raft Association and Signaling Regulate Molecular Clustering at the Immunological Synapse Site1
- Review of the potential health impact of β-casomorphins and related peptides 1
- Anti-Human CD4 Induces Peripheral Tolerance in a Human CD4+, Murine CD4−, HLA-DR+ Advanced Transgenic Mouse Model1
- Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with a nondepleting CD4 antibody.
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