Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

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Summary

The use of a murine CD4 enhancer is described in the generation of transgenic mice expressing physiologic levels of human CD4, which mediates rescue of the CD4 lineage and restoration of normal helper cell functions in mice whose endogenous CD4 gene is inactivated.

Type
article
Published
1993-04-01
Cited by
218
References
2
Access
Open access

Keywords

Expression (computer science), Gerontology, Library science, Environmental ethics, Biology

References

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