Tracking migration during human T cell development
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Summary
The dynamic changes in behavior that occur throughout thymocytes development are discussed, and an overview of the cell-intrinsic and extrinsic mechanisms that regulate human thymocyte migration are provided.
- Type
- review
- Published
- 2014-03-30
- Cited by
- 35
- References
- 148
- Access
- Open access
- OpenAlex
- https://openalex.org/W2049953323
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14638126
Keywords
Thymocyte, Cell biology, Biology, Cell migration, Chemokine receptor
References
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- Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow.
- Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
- Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain
- Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.
- Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice
- The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.
- Distinct temporal pattern of T cell receptor signals during positive versus negative selection in situ
- Differential chemotactic behavior of developing T cells in response to thymic chemokines.
- TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor.
- Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation.
- CCR5- and CXCR4-Utilizing Strains of Human Immunodeficiency Virus Type 1 Exhibit Differential Tropism and Pathogenesis In Vivo
- Macrophage-Derived Chemokine and EBI1-Ligand Chemokine Attract Human Thymocytes in Different Stage of Development and Are Produced by Distinct Subsets of Medullary Epithelial Cells: Possible Implications for Negative Selection1
- Active movement of T cells away from a chemokine
- The impact of negative selection on thymocyte migration in the medulla
- Ontogeny of human T cells.
- T Cell Repertoire Development in Humans with SCID After Nonablative Allogeneic Marrow Transplantation 1
- Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen.
- Exposing the human nude phenotype
- Cutting edge: developmental switches in chemokine responses during T cell maturation.
Cited by
- Pre-TCR ligand binding impacts thymocyte development before αβTCR expression
- Role of Ets Proteins in Development, Differentiation, and Function of T‐Cell Subsets
- Conserved and divergent aspects of human T-cell development and migration in humanized mice
- Laminin-Mediated Interactions in Thymocyte Migration and Development
- Chronic hypoxia in pregnancy affects thymus development in Balb/c mouse offspring via IL2 Signaling
- Growth hormone in the presence of laminin modulates interaction of human thymic epithelial cells and thymocytes in vitro
- MicroRNA-205 Maintains T Cell Development following Stress by Regulating Forkhead Box N1 and Selected Chemokines*
- Loss of CD44dim Expression from Early Progenitor Cells Marks T-Cell Lineage Commitment in the Human Thymus
- Distribution of T-cell markers CD4 and CD8α in lymphoid organs of healthy newborn, juvenile, and adult highland-plateau yaks.
- Small interference ITGA6 gene targeting in the human thymic epithelium differentially regulates the expression of immunological synapse-related genes
- Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality
- Nanostructured Bifunctional Hydrogels as Potential Instructing Platform for Hematopoietic Stem Cell Differentiation
- Tumor progression mechanisms: Insights from the central immune regulation of tissue homeostasis
- The αβTCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site
- Pleiotropic Roles of VEGF on the Microenvironment of the Developing Thymus
- Current and Future Therapeutic Approaches for Thymic Stromal Cell Defects
- Recapitulation of Thymic Function by Tissue Engineering Strategies
- Integrative Single-Cell Transcriptomic Analysis of Human Fetal Thymocyte Development
- Novel Combination of Surface Markers for the Reliable and Comprehensive Identification of Human Thymic Epithelial Cells by Flow Cytometry: Quantitation and Transcriptional Characterization of Thymic Stroma in a Pediatric Cohort
- T-Cell Progenitors As A New Immunotherapy to Bypass Hurdles of Allogeneic Hematopoietic Stem Cell Transplantation
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