Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
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Summary
Evidence is presented for a large class of non-oncogenes that are essential for cancer cell survival and present attractive drug targets and theoretical considerations for combining orthogonal cancer therapies are provided.
- Type
- article
- Published
- 2009-03-06
- Cited by
- 1,840
- References
- 123
- Access
- Open access
- OpenAlex
- https://openalex.org/W2077813812
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8458349
Keywords
Biology, Oncogene, Cancer research, Cancer therapy, Cancer
References
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Cited by
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- Primary resistance to ATP-competitive mTOR inhibitors for the treatment of solid tumors
- Molecular classification and novel targets in hepatocellular carcinoma: recent advancements
- Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy
- Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.
- Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma
- FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators.
- Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin
- Challenges and opportunities for next-generation sequencing in companion diagnostics
- Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells
- Decrease in FOXJ1 expression and its ciliogenesis program in aggressive ependymoma and choroid plexus tumours
- CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials
- P53 prevent tumor invasion and metastasis by down-regulating IDO in lung cancer.
- NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression
- FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy.
- Efficacy of an EGFR-specific peptide against EGFR-dependent cancer cell lines and tumor xenografts.
- The Differential Expression of EGFL7 Transcripts during Angiogenesis in Human Fibrosarcoma
- New druggable targets in the Ras pathway?
- Towards personalized medicine using systems biology and machine learning
- Mechanisms Underlying the Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
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