A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration.
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- Type
- article
- Published
- 1991-02-01
- Cited by
- 249
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1976543436
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22573643
Keywords
Extrachromosomal DNA, Amplicon, Biology, Gene duplication, Genetics
References
- Structure of DNA formed in the first step of CAD gene amplification.
- Structure of an inverted duplication formed as a first step in a gene amplification event: implications for a model of gene amplification.
- Gene amplification in a single cell cycle in Chinese hamster ovary cells.
- Replication program of active and inactive multigene families in mammalian cells
- Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase.
- Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells.
- Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line
- Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells
- Excision of N-myc from chromosome 2 in human neuroblastoma cells containing amplified N-myc sequences
- Evolution and stability of chromosomal DNA coamplified with the CAD gene
- Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea
- Double minute chromosomes can be produced from precursors derived from a chromosomal deletion
- The significance of responses of the genome to challenge.
- Involvement of unstable chromosomal regions containing C-heterochromatin and fragile sites in the integration of amplifieddhfr domains
- Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.
- Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells.
- Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.
- Allelotype of colorectal carcinomas.
- Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
- Effect of gamma rays at the dihydrofolate reductase locus: Deletions and inversions
Cited by
- Mechanisms of MRP over‐expression in four human lung‐cancer cell lines and analysis of the MRP amplicon
- Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity
- MECHANISMS LEADING TO CHROMOSOMAL INSTABILITY IN ORAL CANCER CELLS
- Cancer Cell Heterogeneity
- Regulation of cancer metastasis by stress pathways
- c-Myc, genome instability, and tumorigenesis: the devil is in the details.
- Telomere and Proximal Sequence Analysis Using High-Throughput Sequencing Reads
- Cis and trans requirements for stable episomal maintenance of the BPV‐1 replicator.
- Using control theory to make cancer chemotherapy beneficial from phase dependence and resistant to drug resistance
- Increased methotrexate resistance and dhfr gene amplification as a consequence of induced Ha-ras expression in NIH 3T3 cells.
- Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells.
- Microenvironmental regulation of the initiated cell.
- Branching processes in biology
- Extrachromosomal circular DNA is common in yeast
- Specificity and functional significance of DNA interaction with the nuclear matrix: new approaches to clarify the old questions.
- Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas.
- Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells
- Amplified MYCN in Human Neuroblastoma
- Characterization and functional studies of PPM1D in breast cancer
- Molecular structure and evolution of double-minute chromosomes in methotrexate-resistant cultured mouse cells
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- Extrachromosomal and chromosomal gene conversion in mammalian cells
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