The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus.
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Summary
Defects in insulin secretion and insulin action occur early in the pathogenesis of diabetes, and intervention to prevent diabetes should target both abnormalities.
- Type
- article
- Published
- 1999-09-15
- Cited by
- 1,990
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W2077149049
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11802170
Keywords
Insulin, Internal medicine, Endocrinology, Diabetes mellitus, Insulin resistance
References
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- Oestrogens and endometrial cancer.
- Joslin's Diabetes Mellitus
- Energy expenditure in humans: effects of dietary fat and carbohydrate.
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- Obesity, very low density lipoproteins, and glucose intolerance over fourteen years: The Framingham Study.
- Loss of Early Phase of Insulin Release in Humans Impairs Glucose Tolerance and Blunts Thermic Effect of Glucose
- Physiological Importance of Deficiency in Early Prandial Insulin Secretion in Non-Insulin-Dependent Diabetes
- Effects of Insulin on Body Composition in Patients with Insulin‐dependent and Non‐insulin‐dependent Diabetes
- Analysis of Early-Phase Insulin Responses in Nonobese Subjects With Mild Glucose Intolerance
- Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative.
- Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications
- Risk Factors for NIDDM in White Population: Paris Prospective Study
- Fasting Serum Insulin Concentration and Early Insulin Response as Risk Determinants for Developing Diabetes
- Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.
Cited by
- Zinc as a Potential Coadjuvant in Therapy for Type 2 Diabetes
- Resitin and adiponectin in the Bahraini population : plasma levels, gene polymorphisms and their association with type 2 diabetes and related metabolic parameters.
- Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach.
- Type 2 diabetes: principles of pathogenesis and therapy
- Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats.
- Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds.
- Effects of pioglitazone on beta-cell function in metabolic syndrome patients with impaired glucose tolerance.
- Elevated fasting triglycerides predict impaired glucose tolerance in adolescents at risk for type 2 diabetes
- Complications of hypertension and the role of angiotensin receptor blockers in hypertension trials
- The role for endoplasmic reticulum stress in diabetes mellitus.
- Glycated fetal calf serum affects the viability of an insulin-secreting cell line in vitro.
- Botanicals and the metabolic syndrome.
- Childhood Predictors of Adult Acute Insulin Response and Insulin Action
- Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes
- Clinical application of incretin-based therapy: therapeutic potential, patient selection and clinical use.
- Effect of the urotensin-II receptor antagonist palosuran on secretion of and sensitivity to insulin in patients with Type 2 diabetes mellitus.
- Impact of Different Fat Depots on Insulin Sensitivity: Predominant Role of Liver Fat
- Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study
- Pharmacologic restoration of the early insulin response in pre-diabetic monkeys controls mealtime glucose excursions without peripheral hyperinsulinaemia
- Glucose regulation of β‐cell stress in type 2 diabetes
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- Reply:
- Pharmacological strategies for preventing type 2 diabetes in patients with impaired glucose tolerance.