Glucose regulation of β‐cell stress in type 2 diabetes

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Summary

Stress signalling is a ‘double‐edged sword’ that may promote adaptation or apoptosis according to the balance between the divergent outputs of the various pathways under conditions of metabolic stress, such as occurs under hyperglycaemic conditions.

Type
review
Published
2010-10-01
Cited by
44
References
125
Access
Open access

Keywords

Oxidative stress, Cell biology, Unfolded protein response, Reactive oxygen species, Apoptosis

References

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