Glucose regulation of β‐cell stress in type 2 diabetes
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Summary
Stress signalling is a ‘double‐edged sword’ that may promote adaptation or apoptosis according to the balance between the divergent outputs of the various pathways under conditions of metabolic stress, such as occurs under hyperglycaemic conditions.
- Type
- review
- Published
- 2010-10-01
- Cited by
- 44
- References
- 125
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973281276
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31887160
Keywords
Oxidative stress, Cell biology, Unfolded protein response, Reactive oxygen species, Apoptosis
References
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- Genome–wide association studies provide new insights into type 2 diabetes aetiology
- Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
- PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
- Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion.
- β-cell deterioration during diabetes
- Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis*
- Beta cell apoptosis in diabetes
- Initiation and execution of lipotoxic ER stress in pancreatic β-cells
- Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding Proteins
- The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells
- Thioredoxin-independent Regulation of Metabolism by the α-Arrestin Proteins*
- Characterization of Pancreatic Transcription Factor Pdx-1 Binding Sites Using Promoter Microarray and Serial Analysis of Chromatin Occupancy*
Cited by
- Regulation of pancreatic β-cell survival by nitric oxide
- Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells
- Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model
- Bioactive components from flowers of Sambucus nigra L. increase glucose uptake in primary porcine myotube cultures and reduce fat accumulation in Caenorhabditis elegans.
- SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
- The Thioredoxin System as a Therapeutic Target in Human Health and Disease
- Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes
- TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
- Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling.
- Melatonin prevents pancreatic β‐cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress
- Mitochondrial Effects of Plant-Made Compounds
- Diabetes and beta cell function: from mechanisms to evaluation and clinical implications
- Role of ceramide in diabetes mellitus: evidence and mechanisms
- Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress
- Association between ferritin and hepcidin levels and inflammatory status in patients with type 2 diabetes mellitus and obesity.
- Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity.
- Suppression of pancreatic beta cell apoptosis by Danzhi Jiangtang capsule contributes to the attenuation of type 1 diabetes in rats
- Lipoapoptosis Pathways in Pancreatic β-Cells and the Anti-Apoptosis Mechanisms of Adiponectin
- Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells
- Mathematical models of mechanisms underlying long-term type 2 diabetes progression
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