An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
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Summary
The results reveal a previously unknown link between genes associated with ES cell identity and the histopathological traits of tumors and support the possibility that these genes contribute to stem cell–like phenotypes shown by many tumors.
- Type
- article
- Published
- 2008-05-01
- Cited by
- 2,564
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W2073759231
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6891030
Keywords
Biology, Embryonic stem cell, Stem cell, Gene signature, Gene expression
References
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- An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival.
- Tcf3 governs stem cell features and represses cell fate determination in skin.
- A Meta‐Analysis of Human Embryonic Stem Cells Transcriptome Integrated into a Web‐Based Expression Atlas
- Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
- From signatures to models: understanding cancer using microarrays
- Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
- Tissue-Specific Transcriptional Regulation has Diverged Significantly between Human and Mouse
- Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma.
- Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.
- Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
- Integrative analysis of the cancer transcriptome
- Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer
- MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
- Embryonic Stem Cell Transcription Factor Signatures in the Diagnosis of Primary and Metastatic Germ Cell Tumors
- How is pluripotency determined and maintained?
- Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
- Concordance among gene-expression-based predictors for breast cancer.
- Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
- Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
Cited by
- Advances in Cancer Stem Cell Biology
- Cell cycle regulation by microRNAs in stem cells.
- Cancer stem cells, hypoxia and metastasis.
- Mechanisms of Polycomb gene silencing: knowns and unknowns
- Meis1 maintains stemness signature in MLL-AF9 leukemia.
- Transcriptional regulation of cellular senescence
- The tumor suppressor role of CTCF
- Molecular pathology of tumor‐initiating cells: Lessons from Philadelphia chromosome‐positive leukemia
- A specific increase in inositol 1,4,5-trisphosphate 3-kinase B expression upon differentiation of human embryonic stem cells.
- The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic sites
- SOX2 Expression and Prognostic Significance in Ovarian Carcinoma
- DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
- Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment
- p53 orchestrates between normal differentiation and cancer.
- Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 lysine 27 trimethylation
- The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update
- Antisense transcription at the TRPM2 locus as a novel prognostic marker and therapeutic target in prostate cancer
- Overlapping DNA Methylation Dynamics in Mouse Intestinal Cell Differentiation and Early Stages of Malignant Progression
- Sox2: regulation of expression and contribution to brain tumors.
- Epithelial–mesenchymal transition promotes SOX2 and NANOG expression in bladder cancer
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