MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
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Summary
It is reported that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers and how oncogenic inactivation may reverse tumorigenesis in the most clinically difficult cancers is shown.
- Type
- article
- Published
- 2004-10-28
- Cited by
- 899
- References
- 46
- OpenAlex
- https://openalex.org/W2054657650
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4412899
Keywords
Biology, Cytokeratin, Carcinogenesis, Cancer research, Oncogene
References
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- Therapeutic implications of cancer stem cells.
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- Mechanisms of human hepatocarcinogenesis.
- Kinetic Characterization of Bifunctional Thymidylate Synthase-Dihydrofolate Reductase (TS-DHFR) from Cryptosporidium hominis
- Solitary cancer cells as a possible source of tumour dormancy?
- Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
- Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC
- Y chromosomal SNP genotyping using oligonucleotide microarrays: comparison of different oligonucleotide immobilization chemistries
- Cancer dormancy: Opportunities for new therapeutic approaches
- Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
- The role of hepatocytes and oval cells in liver regeneration and repopulation.
- Reversible tumorigenesis by MYC in hematopoietic lineages.
- Growth of Toxoplasma gondii is inhibited by aryloxyphenoxypropionate herbicides targeting acetyl-CoA carboxylase.
Cited by
- Rehabilitation of cancer through oncogene inactivation.
- The Chromosomal Basis of Cancer
- Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch
- Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-β signaling
- Current progress in epigenetic research for hepatocarcinomagenesis
- Targeting MYC-Regulated miRNAs to Combat Cancer.
- Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
- c‐Myc‐mediated epigenetic silencing of MicroRNA‐101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma
- The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update
- Tumor Dormancy, Oncogene Addiction, Cellular Senescence and Self-Renewal Programs
- MYC: connecting selective transcriptional control to global RNA production
- Stem cell technology in breast cancer: current status and potential applications
- Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells
- Genetically engineered animal models for in vivo target identification and validation in oncology.
- Small-molecule modulators of c-Myc/Max and Max/Max interactions.
- Tumor dormancy and cancer stem cells: two sides of the same coin?
- Identifying critical signaling molecules for the treatment of cancer.
- MYC-induced lymphomagenesis Inhibition of HMGcoA reductase by atorvastatin prevents and reverses
- Function and regulation of myc-family bHLHZip transcription factors during the animal and plant cell cycle
- Targeting c-Myc as a novel approach for hepatocellular carcinoma.
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