MDM2: life without p53.
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Summary
This work has shown that the MDM2 protein suppresses the ability of p53 to inhibit cellular proliferation or to induce cell death, and also has p53-independent activities, which are focused on here.
- Type
- review
- Published
- 2001-08-01
- Cited by
- 105
- References
- 60
- OpenAlex
- https://openalex.org/W2071219133
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31509288
Keywords
Mdm2, Biology, Cell biology, Cancer research, P53 protein
References
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- Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
- The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain
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- p14ARF links the tumour suppressors RB and p53
- The Pezcoller lecture: cancer cell cycles revisited.
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- Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
- MDM2--master regulator of the p53 tumor suppressor protein.
- The cat and mouse games that genes, viruses, and cells play.
- Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
- Human oncoprotein mdm2 interacts with the tata-binding protein in-vitro and in-vivo.
- MDM2 and MDMX bind and stabilize the p53-related protein p73.
- The cellular response to p53: the decision between life and death
- Interaction between the retinoblastoma protein and the oncoprotein MDM2
- p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.
- RB regulates the stability and the apoptotic function of p53 via MDM2.
- Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
- The ARF/p53 pathway.
- Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
Cited by
- EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response*
- Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.
- Critical and Independent Roles of the P/CAF Acetyltransferase in ARF-p53 Signaling: A Dissertation
- P53 and other cell cycle regulators.
- Allosteric regulation of MDM2 protein
- Tumor suppressor p53 and transcriptional changes in cellular stress responses to UV radiation
- Sensitization of Prostate Cancer Cells to Androgen Deprivation and Radiation via Manipulation of the MDM2 Pathway
- The p53 and Mdm2 families in cancer.
- Regulation of FOXO stability and activity by MDM2 E3 ligase
- Mdm2: A regulator of cell growth and death.
- Protein-protein interactions and multi-component complexes of aminoacyl-tRNA synthetases.
- Transcriptional activities of mutant p53: When mutations are more than a loss
- Functional characterization of human oncoprotein gankyrin in Zebrafish
- Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABAA receptors
- Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells
- Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer
- Clinical significance of MDM2 as a tumor biomarker
- Molecular mechanisms of survival and apoptosis in RAW 264.7 macrophages under oxidative stress
- MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC).
- Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
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