Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
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Summary
The data suggest that the MDM2 protein, which is induced by p53, functions as a ubiquitin ligase, E3, in human papillomavirus‐uninfected cells which do not have E6 protein.
- Type
- article
- Published
- 1997-12-22
- Cited by
- 2,084
- References
- 28
- OpenAlex
- https://openalex.org/W9450543
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29014813
Keywords
Business, Computer science
References
- cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript.
- mdm2 expression is induced by wild type p53 activity.
- Cyclin G is a transcriptional target of the p53 tumor suppressor protein.
- In vivo ubiquitination and proteasome-mediated degradation of p53(1).
- Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
- Fission yeast Cut2 required for anaphase has two destruction boxes
- p53 in growth control and neoplasia.
- A novel form of Epstein-Barr virus latency in normal B cells in vivo.
- A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
- Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade
- Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase.
- WAF1, a potential mediator of p53 tumor suppression.
- The mdm-2 gene is induced in response to UV light in a p53-dependent manner.
- Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.
- Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.
- A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
- Regulation of p53 stability by Mdm2
- Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5 (*)
- The ubiquitin-proteasome proteolytic pathway.
- Cloning and sequence of a functionally active cDNA encoding the mouse ubiquitin-activating enzyme E1.
Cited by
- Genetik des Aderhautmelanoms
- MDM2 overexpression, activation of signaling networks, and cell proliferation.
- Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.
- Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
- Regulation of p53 stability
- Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).
- Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.
- Regulation of transcription factors by protein degradation
- Compartment-specific functions of the ubiquitin-proteasome pathway.
- Regulation of p53 function.
- N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.
- EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response*
- Mdm-2 binding and TAFII31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21
- Improving cancer therapy by non-genotoxic activation of p53.
- The role of tumor suppressor p53 in the antioxidant defense and metabolism
- Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrations.
- Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53*
- The ubiquitin-proteasome pathway and its role in cancer.
- The ubiquitin-proteasome system: focus on the heart.
- Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2.
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