Interaction between the retinoblastoma protein and the oncoprotein MDM2
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Summary
Here it is shown that MDM2 interacts physically and functionally with pRB and, as with p53, inhibits pRB growth regulatory function, therefore, both p RB and p53 can be subjected to negative regulation by the product of a single cellular proto-oncogene.
- Type
- article
- Published
- 1995-06-22
- Cited by
- 631
- References
- 30
- OpenAlex
- https://openalex.org/W1986512406
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4318099
Keywords
Retinoblastoma protein, Carcinogenesis, Retinoblastoma, Biology, Mdm2
References
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- Tumor suppressor genes.
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- Identification of a growth suppression domain within the retinoblastoma gene product.
- The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner.
- E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
- Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
- Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product.
- Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+.
- Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.
- Cooperative tumorigenic effects of germline mutations in Rb and p53
- Amplification of a gene encoding a p53-associated protein in human sarcomas
Cited by
- MDM2 overexpression, activation of signaling networks, and cell proliferation.
- Disruption of actin microfilaments by cytochalasin D leads to activation of p53
- Aberrant expression of the cell cycle associated proteins TP53, MDM2, p21, p27, cdk4, cyclin D1, RB, and EGFR in cervical carcinomas.
- The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF
- Regulation of p53 stability
- Overexpression of MDM2 protein in intrahepatic cholangiocarcinoma: relationship with p53 overexpression, Ki-67 labeling, and clinicopathological features
- Regulation of p53 function.
- Ultraviolet B-induced melanoma in Monodelphis domestica occurs in the absence of alterations in the structure or expression of the p53 gene
- The INK4a/ARF locus and human cancer.
- Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.
- A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein
- MDM2 interacts with and downregulates a sarcomeric protein, TCAP.
- Lamin A/C, laminopathies and premature ageing.
- Expression and function of cell cycle proteins in rheumatoid arthritis synovial tissue.
- Dissecting the telomere-independent pathways underlying human cellular senescence
- Regulation of NFκB/P65 by MDM2 in pediatric acute lymphoblastic leukemia
- Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.
- Integration of the PRB and P53 Cell Cycle Control Pathways
- Big brothers are watching: the retinoblastoma family and growth control.
- Unbound E2F modulates TGF-β1-induced apoptosis in HuH-7 cells
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