MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC).

Keywords

Medicine, Mdm2, Lung cancer, Internal medicine, Oncology

References

• Mdm2: The Ups and DownsTamar Juven‐Gershon, Moshe Oren — 1999
• Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.S. Fakharzadeh, Stephen P. Trusko, Donna L. George — 1991
• The mdm2 proto-oncogene.Dale S. Haines — 1997
• Gene amplification as a prognostic factor in primary brain tumors.Jeffrey J. Olson, David W. Barnett, Jing Yang — 1998
• TP53 mutational pattern in Spanish and Polish non-small cell lung cancer patients: null mutations are associated with poor prognosisJosep Maria de Anta, Ewa Jassem, Rafael Rosell — 1997
• Results of surgical treatment of non-small cell lung cancer: validation of the new postoperative pathologic TNM classification.Jacek Jassem, Jan Skokowski, Rafał Dziadziuszko — 2000
• MDM2 expression is associated with progress of disease and WAF1 expression in resected lung cancer.H Aikawa, Masami Sato, S Fujimura — 2000
• MDM2 amplification and loss of heterozygosity at Rb and p53 genes: no simultaneous alterations in the oncogenesis of liposarcomasHajo Walter, Kathrin Radig, Janusz Ryś — 1998
• Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors.Ryohei Yokoyama, Regine Schneider‐Stock, Kathrin Radig — 1998
• Molecular pathology of primary and metastatic ductal pancreatic lesionsBruce Ruggeri, Lingyi Huang, David Berger — 1997
• Infrequent mutations of the TP53 gene and no amplification of the MDM2 gene in hepatoblastomasH. Ohnìshì, Machiko Kawamura, Ryoji Hanada — 1996
• TP53 mutations and MDM2 gene amplification in squamous‐cell carcinomas of the esophagus in South ThailandPhilippe Tanière, Ghyslaine Martel‐Planche, Puttisak Puttawibul — 2000
• Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma.Qian Wang, Li–Fu Hu, Fu Chen — 1995
• Clinical implications of molecular abnormalities in lung cancer.Rafał Dziadziuszko, Ewa Jassem, Jacek Jassem — 1998
• Histological Typing Of Lung TumorsOscar Auerbach — 1968
• mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations.Antonio Marchetti, F Buttitta, Silvia Pellegrini — 1995
• Analysis of human telomerase reverse transcriptase mRNA (hTERT) expression in myxoid liposarcomas using LightCycler real‐time quantitative reverse transcriptase‐polymerase chain reactionRegine Schneider‐Stock, Thomas Emrich, Brigitte Peters — 2001
• Mdm2 Gene Amplification in Gastric Cancer Correlation with Expression of Mdm2 Protein and p53 AlterationsThomas Günther Pomorski, Regine Schneider‐Stock, Carsten Häckel — 2000
• Prognostic relevance of proliferating cell nuclear antigen and p53 expression in non-small cell lung cancer.Dorota Dworakowska, Stanisław Góźdż, Ewa Jassem — 2002
• Amplification of the mdm2 gene, but not expression of splice variants of mdm2 mrna, is associated with prognosis in soft tissue sarcomaFrank Bartel, Axel Meye, Peter W�rl — 2001

Cited by

• Identificación mediante inmunohistoquímica de factores pronósticos biomoleculares en el carcinoma broncogénico no microcítico en estadio precoz resecadoJ. R. J. Sarceda — 2014
• Allosteric regulation of MDM2 proteinBartosz Wawrzynów — 2010
• Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment.Loredana Urso, Fiorella Calabrese, Adolfo Favaretto — 2016
• Multiple modes of Mdmx regulation affect p53 activationDaniele M. Gilkes — 2008
• Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1Xiao‐Xin Sun, Kishore B. Challagundla, Mu‐Shui Dai — 2011
• Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1.Xiao‐Xin Sun — 2014
• Characterization of adenocarcinoma of the lung in a familial adenomatous polyposis patientKazuya Shinmura, Masaya Suzuki, Hidetaka Yamada — 2008
• Molecular Biology of Lung Cancer: Clinical ImplicationsKwun M. Fong, John D. Minna — 2002
• The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinomaCéline Mascaux, Frederick J. Bex, Benoı̂t Martin — 2008
• Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristicsRobert Stoehr, Florian Hitzenbichler, Burkhard Kneitz — 2008
• Regulating the p53 pathway: in vitro hypotheses, in vivo veritasFranck Toledo, Geoffrey M. Wahl — 2006
• Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluationC-Q Zhu, Warren Shih, C-H Ling — 2006
• Identification of the 12q15 Amplicon within the Homogeneously Staining Regions in the Embryonal Rhabdomyosarcoma Cell Line RMS-YMNaoki Kakazu, H Yamane, Mitsuru Miyachi — 2014
• Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism*Mu-Shui Dai, Dingding Shi, Yetao Jin — 2006
• Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapyTiffany DeVine, Mu‐Shui Dai — 2013
• Expression and significance of MMP-9 and MDM2 in the oncogenesis of lung cancer in rats.De-Hui Zhang, Liang-Yu Zhang, Dongjie� Liu — 2014
• Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?Subhasree Nag, X. Zhang, Kalkunte S. Srivenugopal — 2014
• Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancerXuemei Zhang, Xiaoping Miao, Yongli Guo — 2006
• Regulation of the DNA damage response by ubiquitin conjugationKerstin Brinkmann, Michael J. Schell, Thorsten Hoppe — 2015
• Prognostic value of the apoptotic index analysed jointly with selected cell cycle regulators and proliferation markers in non-small cell lung cancer.Dorota Dworakowska, Ewa Jassem, Jacek Jassem — 2009

Related papers

• EGFR, TTF-1 and Mdm2 expression in stage III non-small cell lung cancer: a positive association.Thierry Berghmans, Céline Mascaux, Annick Haller — 2008
• miR-181 Expression is Associated With The Prognosis in Lung Cancer.Yue Zhao, Xiangjun Kong, Hongbing Wang — 2020
• Prognostic factors for patients with gliomaYuan Ju — 2005
• Marital Status Independently Predicts Survival in Patients with Small Cell Lung Cancer: A SEER Database Analysis2022
• Metastatic renal cell carcinoma patients of T4 stage who are in status of N1 stage or older than 76 years cannot benefit from Cytoreductive NephrectomyZhao Zhang, Hongliang Wu, Tong Yang — 2020
• [Multivariate analysis of recurrence factors for non muscle-invasive bladder urothelial carcinomas].Junxing Chen, Nan Deng, Lingwu Chen — 2010
• Analysis of clinical characteristics and prognostic factors of elderly patients with renal cell carcinoma based on SEER databaseXiaoyan Peng, Hui Sun, Tianyi Guo — 2021
• Metastatic renal cell carcinoma patients of T4 stage who are in status of N1 stage or older than 76 years cannot benefit from Cytoreductive NephrectomyZhao Zhang, Hongliang Wu, Tong Yang — 2020