Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
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Summary
It is demonstrated that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor, and increases in interferon-gamma production and natural killer cell activity in response to IL- 18 are abrogated.
- Type
- article
- Published
- 1998-07-01
- Cited by
- 2,338
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W2070597700
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:411609
Keywords
Biology, Signal transducing adaptor protein, Signal transduction, Cell biology, Receptor
References
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- pEF-BOS, a powerful mammalian expression vector.
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- The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein.
- Drosophila Toll and IL-1 receptor
- T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family (*)
- The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo.
Cited by
- Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation
- Immune Cell Activation by Bacterial Cpg-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor–Associated Factor (Traf)6
- Toll‐like receptors: molecular mechanisms of the mammalian immune response
- Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.
- MAP kinases in the immune response.
- Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway.
- CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
- The immunogenic peptide for Th1 development.
- A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
- Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent
- Islet Xenotransplantation : An Experimental Study of Barriers to Clinical Transplantation
- Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice
- Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
- Identification of Card15/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats.
- Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta.
- Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury.
- NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs
- Toll-like Receptor 2 Senses β-Cell Death and Contributes to the Initiation of Autoimmune Diabetes
- Engagement of Toll‐like receptor‐2 on cytotoxic T‐lymphocytes occurs in vivo and augments antitumor activity
- The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
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