Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
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Summary
Induction of the B7-H1/PD-1 pathway may represent an adaptive immune resistance mechanism exerted by tumor cells in response to endogenous antitumor activity and may explain how melanomas escape immune destruction despite endogenous antitUMor immune responses.
- Type
- article
- Published
- 2012-03-28
- Cited by
- 2,140
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W2057893793
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:526274
Keywords
Immune system, Melanoma, Antigen, Tumor-infiltrating lymphocytes, Immunology
References
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- B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
- Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance.
- Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
- Mononuclear cell infiltration in clear‐cell renal cell carcinoma independently predicts patient survival
- Distinct sets of genetic alterations in melanoma.
- The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors.
- Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
- Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
- Malignant melanoma of unknown primary site. To make the long story short. A systematic review of the literature.
- Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
- Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
- Inhibitory B7-family molecules in the tumour microenvironment
- Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
- Gene Signature in Melanoma Associated With Clinical Activity: A Potential Clue to Unlock Cancer Immunotherapy
- Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
- Overall survival and PD‐L1 expression in metastasized malignant melanoma
- An immune-active tumor microenvironment favors clinical response to ipilimumab
Cited by
- Prognostic value of immune cell infiltration, tertiary lymphoid structures and PD-L1 expression in Merkel cell carcinomas.
- Merkel polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers
- Endocrine side-effects of anti-cancer drugs: mAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses.
- PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics.
- PD-1 blockade therapy in renal cell carcinoma: current studies and future promises.
- HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade
- The Immune Checkpoint Regulator PD-L1 Is Highly Expressed in Aggressive Primary Prostate Cancer
- Programmed death ligand 1 expression in triple‐negative breast cancer is associated with tumour‐infiltrating lymphocytes and improved outcome
- Cancer immune contexture and immunotherapy.
- A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints
- Increased Infiltration of CD8+ T Cells by Dacarbazine in a Patient with Mucosal Penile Melanoma Refractory to Nivolumab
- The promise of PD-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. PD-L1.
- Combining Radiation Therapy with Immune Checkpoint Blockade for Central Nervous System Malignancies
- Programmed Death-Ligand 1 Expression, Microsatellite Instability, Epstein–Barr Virus, and Human Papillomavirus in Nasopharyngeal Carcinomas of Patients from the Philippines
- Targeting the PD-1/PD-L1 axis in multiple myeloma: a dream or a reality?
- Transcriptional mechanisms of resistance to anti-PD-1 therapy
- Expression patterns of programmed death-ligand 1 in esophageal adenocarcinomas: comparison between primary tumors and metastases
- NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27
- Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy
- DNA Damage and Repair Biomarkers of Immunotherapy Response
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