Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
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Summary
Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation, and is vital for the control of lymphocyte homeostasis.
- Type
- letter
- Published
- 1995-11-10
- Cited by
- 3,022
- References
- 34
- OpenAlex
- https://openalex.org/W2015085911
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45993765
Keywords
CTLA-4, T cell, Receptor, Biology, Cell biology
References
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- The ups and downs of T cell costimulation.
- The B7 and CD28 receptor families.
- Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.
- DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement.
- Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
- Absence of B7-dependent responses in CD28-deficient mice.
- Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
- Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.
- A new member of the immunoglobulin superfamily—CTLA-4
- CTLA-4 can function as a negative regulator of T cell activation.
- An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
- Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.
- Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.
- Lethal effect of the anti-Fas antibody in mice
Cited by
- T cell signaling: a decision of life and death.
- Expression of cytotoxic T lymphocyte antigen-4 in T cells from children with Hashimoto's thyroiditis.
- Autoimmune Thyroid Diseases
- Signaling events in T lymphocytes leading to cellular activation or programmed cell death.
- Caractérisation immunologique et protéomique des cellules dendritiques tolérogènes humaines. Application à la recherche de biomarqueurs de l’immunothérapie spécifique allergénique
- Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes
- CTLA-4 Ligation Suppresses CD28-induced NF-κB and AP-1 Activity in Mouse T Cell Blasts*
- Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo.
- CD28-Specific Antibody Prevents Graft-Versus-Host Disease in Mice1
- Inhibition of IgG1 and IgE Production by Stimulation of the B Cell CTLA-4 Receptor1
- Patients with neoplastic and nonneoplastic hematologic diseases acquire CTLA‐4 antibodies after blood transfusion
- New approaches to treatment in systemic vasculitis: biological therapies.
- Genetics of asthma and atopy
- CTLA-4 Differentially Regulates T Cell Responses to Endogenous Tissue Protein Versus Exogenous Immunogen1
- Costimulatory Molecule Immune Enhancement in a Plasmid Vaccine Model Is Regulated in Part Through the Ig Constant-Like Domain of CD80/86 1
- Two different forms of human CTLA-4 proteins following peripheral T cell activation.
- Commentary: Regulated equilibrium between opposite signals: a general paradigm for T cell function?
- Experimental use of murine lupus models.
- Clinical application of human CD4+CD25+ regulatory Tcells for the treatment of inflammatory bowel diseases
- Mechanisms of CTLA-4-Ig in tolerance induction.
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