Increased Infiltration of CD8+ T Cells by Dacarbazine in a Patient with Mucosal Penile Melanoma Refractory to Nivolumab
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Summary
A case of a 60-year-old Japanese male with a mucosal penile melanoma and an increased CD8+ T cell infiltration in brain after dacarbazine (DTIC) administration is reported, which could be the first step to discuss the development of effective therapies against melanoma to take advantage of the increased CD 8+ Tcell infiltration elicited by chemotherapeutic agents.
- Type
- article
- Published
- 2016-07-26
- Cited by
- 7
- References
- 8
- Access
- Open access
- OpenAlex
- https://openalex.org/W27489432
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14872582
Keywords
Computer science
References
- Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.
- Immunohistological analysis of in‐transit metastasis in a patient with advanced melanoma treated with combination therapy of cytosine guanine dinucleotide oligodeoxynucleotide, dacarbazine and beta‐interferon: A case report
- Dacarbazine promotes stromal remodeling and lymphocyte infiltration in cutaneous melanoma lesions.
- Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
- Cancer chemotherapy agents target intratumoral dendritic cells to potentiate antitumor immunity
- Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
- Dacarbazine in melanoma: from a chemotherapeutic drug to an immunomodulating agent.
- Primary malignant melanoma of the urethra: a clinicopathologic analysis of 15 cases.
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- Case of malignant melanoma responding to dacarbazine following nivolumab
- The immunocytokine L19-TNF eradicates Sarcomas in combination with Chemotherapy or with immune check-point inhibitors
- Combined cytotoxic chemotherapy and immunotherapy of cancer: modern times
- The immunocytokine L19-TNF eradicates sarcomas in combination with chemotherapy agents or with immune check-point inhibitors
- Rechallenge of programmed cell death 1 inhibitor after an interval with dacarbazine treatment may be effective for advanced malignant melanoma.
- Co-delivery of PDL1-blocking scFv and chemotherapeutics using engineered exosomes for cancer therapy
- Effects of temozolomide on tumor mutation burden and microsatellite instability in melanoma cells
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