Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Keywords

RHEB, TSC2, TSC1, P70-S6 Kinase 1, PI3K/AKT/mTOR pathway

References

• Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.Tiara Tama, Evania Try — 2002
• Regulation of mammalian translation factors by nutrients.Christopher G. Proud — 2002
• rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.Kanato Yamagata, Lori K. Sanders, Walter E. Kaufmann — 1994
• Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.Kathleen E. Mach, Kyle A. Furge, Charles F. Albright — 2000
• Tsc tumour suppressor proteins antagonize amino-acid–TOR signallingXinsheng Gao, Yong Zhang, Peter Arrazola — 2002
• Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY (*)Ralf Wienecke, Adrian König, Jeffrey E. DeClue — 1995
• GTPase-activating proteins: helping hands to complement an active site.Klaus Scheffzek, Mohammad Reza Ahmadian, Alfred Wittinghofer — 1998
• Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients.Kit Sing Au, Joseph Rodriguez, Jennifer L. Finch — 1998
• Phosphatidic Acid-Mediated Mitogenic Activation of mTOR SignalingYimin Fang, Montserrat Vilella-Bach, Rebecca Bachmann — 2001
• FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunctionBimal N. Desai, Benjamin R. Myers, Stuart L. Schreiber — 2002
• Control of p70 S6 kinase by kinase activity of FRAP in vivoEric J. Brown, Peter A. Beal, Curtis T. Keith — 1995
• Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism*Kenta Hara, Kazuyoshi Yonezawa, Qing-Ping Weng — 1998
• Mammalian TOR: A Homeostatic ATP SensorPatrick B. Dennis, Anja Jaeschke, Masao Saitoh — 2001
• TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingKen Inoki, Yong Li, Tianquan Zhu — 2002
• A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in miceToshiyuki Kobayashi, Osamu Minowa, Yoshinobu Sugitani — 2001
• The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.Nicolas Tapon, Naoto Ito, Barry J. Dickson — 2001
• A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants.Meg Trahey, Frank McCormick — 1987
• Tuberous Sclerosis: from Tubers to mTORD J Kwiatkowski — 2003
• Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.Christopher J. Potter, He Huang, Tian Xu — 2001
• The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation*Geoffrey Clark, Michael S. Kinch, Kelley Rogers-Graham — 1997

Cited by

• Overview of cancer molecular radiobiology.Jann N. Sarkaria, Robert G. Bristow — 2008
• Role of GLUT1 in the Mammalian Target of Rapamycin Pathway: Mechanisms of Regulation.Carolyn L. Buller — 2010
• Unlocking the code of 14-3-3Ernest W. Hartung — 2004
• Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl.G. x bc, Yag-Ston Saṅs-Rgyas-Dpal — 2005
• Dysregulation of the TSC-mTOR pathway in human diseaseCarmen Banacloche Palao — 2004
• Negative regulation of TSC1-TSC2 by mammalian D-type cyclins.John Nash, Marcelo Covián — 2005
• Therapeutic targets: MTOR and related pathwaysRuth Meissner, Philip Nel, N. S. H. Smit — 2006
• Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in DrosophilaKochi Cmfri — 2007
• Targeting the Phosphatidylinositol 3-Kinase Pathway in Airway Smooth MuscleVera P. Krymskaya — 2012
• Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation.Akinchan Buddhodev Sinha — 2008
• Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation.Jean Pinon — 2008
• Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia.James R. Dalkin, Lisa A. Snyder — 2009
• Phosphatidylinositol 3-kinase (PI3K): The OncoproteinPeter K. Vogt, Jonathan R. Hart, Marco Gymnopoulos — 2010
• Comparing the roles of the p110α and p110β isoforms of PI3K in signaling and cancer.F. Pérez Padrón, P. Rodríguez López — 2010
• Oocyte and Cumulus Cell Transcripts from Cultured Mouse Follicles Are Induced to Deviate from Normal In Vivo Conditions by Combinations of Insulin, Follicle-Stimulating Hormone, and Human Chorionic Gonadotropin1Lana Muraskin, Stephanie Stullich — 2011
• Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive DrugsGuillermo Roa Zubia — 2011
• Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathwayMeijuan Chen, Yuhong Du, Min Qui — 2012
• TORC1 Signaling Is Governed by Two Negative Regulators in Fission YeastJoanne Pei Sze Yeoh — 2013
• What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-kinase PathwayMulham Alfatama, Kausar Ahmad, Farahidah Mohamed — 2013
• Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagyRavi P. Gupta — 2014

Related papers

• TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1Christian C. Dibble, Winfried Elis, Suchithra Menon — 2012
• Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathwayJarosław Jóźwiak, Sergiusz Jóźwiak, Tomasz Grzela — 2007
• Tuberous sclerosis complex and the mTOR pathwayKi Joong Kim — 2011
• Tuberin, p27 and mTOR in different cellsS. Burgstaller, Margit Rosner, C. Lindengrün — 2009
• TSC2: filling the GAP in the mTOR signaling pathway.Yinghui Li — 2004
• The Neurodevelopmental Pathogenesis of Tuberous Sclerosis Complex (TSC)David M. Feliciano — 2020
• The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.Takahiro Nobukuni, George Thomas — 2004
• The tuberous sclerosis complex: balancing proliferation and survival.Romana Tomasoni, Anna Mondino — 2011
• Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingAndrew R. Tee, Diane C. Fingar, Brendan D. Manning — 2002