Regulation of mammalian translation factors by nutrients.
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Summary
Data indicate the operation of additional, and so far unknown, regulatory mechanisms that control eIF2B activity, which controls the recruitment of the initiator methionyl-tRNA to the ribosome and is activated by insulin in the absence of glucose or amino acids.
- Type
- review
- Published
- 2002-11-01
- Cited by
- 409
- References
- 110
- Access
- Open access
- OpenAlex
- https://openalex.org/W1499618890
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37587614
Keywords
eIF2, Protein biosynthesis, Eukaryotic initiation factor, Translation (biology), Initiation factor
References
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- Control of translation by the target of rapamycin proteins.
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- Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
- Purification of a hepatic S6 kinase from cycloheximide-treated Rats.
- Control of hepatic proteolysis by leucine and isovaleryl-L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma membrane.
- The role of amino acids in the regulation of protein synthesis in perfused rat liver. I. Reduction in rates of synthesis resulting from amino acid deprivation and recovery during flow-through perfusion.
- Regulation of peptide-chain elongation in mammalian cells.
- AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?
- Regulation of protein synthesis in heart muscle. II. Effect of amino acid levels and insulin on ribosomal aggregation.
- The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
- Repression of cap‐dependent translation by 4E‐binding protein 1: competition with p220 for binding to eukaryotic initiation factor‐4E.
- Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes.
- Postprandial stimulation of muscle protein synthesis is independent of changes in insulin.
- AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.
- Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.
- Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells.
- The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
Cited by
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- Amino acid signaling and the control of autophagy [ch 16]
- Nutrigenetics and nutrigenomics of caloric restriction.
- Establishing a role for specific nutrients in Drosophila dietary restriction
- The role of amino acids in liver protein metabolism under a high protein diet : identification of amino acids signal and associated transduction pathways
- Influence of protein nutrition and exercise on muscle metabolism.
- Signal transduction in skeletal muscle mediating responses to phenotype altering signals
- The modulation of reactive oxygen species production from human polymorphonuclear cells by curdlan derivatives as dectin-1 agonists/antagonists.
- Amino acid-sensing mTOR signaling.
- Nutrition and Football : The FIFA/FMARC Consensus on Sports Nutrition
- Reinitiation of translation and ribosome recycling are two distinct mechanisms in Saccharomyces cerevisiae
- Modulation of skeletal muscle insulin sensitivity and SNAT2 amino acid transporter expression by fatty acid availability
- Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats.
- The control of ribosomal RNA synthesis in mammalian cells
- Proteomic analysis of cell wall in four pathogenic species of Candida exposed to oxidative stress.
- Investigating the Restraints Upon Recombinant Protein Production in Mammalian Cells via the Manipulation of eEF2, eEF2K and mTOR
- ГЕТЕРОГЕННОСТЬ ПЕРВИЧНЫХ БОЛЬНЫХ РЕВМАТОИДНЫМАРТРИТОМ ПО ЭКСПРЕССИИ ГЕНОВ В КРОВИ: ТЕОРЕТИЧЕСКИЕ ОСНОВЫ ДИФФЕРЕНЦИАЛЬНОГО ПОДХОДАК ТЕРАПИИ
- Therapeutic interventions against symptoms or disease caused by the ribotoxic stressors: shinga toxin & doxorubicin : a thesis
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