GTPase-activating proteins: helping hands to complement an active site.

Keywords

GTPase, GTP', GTPase-activating protein, Active site, Effector

References

• The N‐terminal region of GAP regulates cytoskeletal structure and cell adhesion.Jane McGlade, Beatrice Brunkhorst, Dirk Anderson — 1993
• The interaction of Ras with GTPase‐activating proteinsAlfred Wittinghofer, Klaus Scheffzek, Mohammad Reza Ahmadian — 1997
• Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.Jacob John, Matthias Frech, Alfred Wittinghofer — 1988
• Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.Carole A. Lancaster, Pamela M. Taylor-Harris, Annette J. Self — 1994
• Fluoride is not an activator of the smaller (20-25 kDa) GTP-binding proteins.Richard Kahn — 1991
• Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target.Paul Polakis, Frank McCormick — 1993
• Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activityPeter Gideon, J John, Matthias Frech — 1992
• Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogueKatrin Rittinger, P.A. Walker, John F. Eccleston — 1997
• GAPs for rho-related GTPases.Nathalie Lamarche, Alan Hall — 1994
• Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.Matthias Geyer, Thomas Schweins, Christian Herrmann — 1996
• Structural Differences in the Minimal Catalytic Domains of the GTPase-activating Proteins p120GAP and Neurofibromin*Mohammad Reza Ahmadian, Lisa Wiesmüller, Alfred Lautwein — 1996
• Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue.Keith J. M. Moore, Martin R. Webb, John F. Eccleston — 1993
• Signaling mechanistics: aluminum fluoride for molecule of the year.Alfred Wittinghofer — 1997
• The ARF1 GTPase-Activating Protein: Zinc Finger Motif and Golgi Complex LocalizationEdna Cukierman, Irit Huber, Miriam Rotman — 1995
• The GTPase superfamily: conserved structure and molecular mechanismHenry R. Bourne, D.A.R. Sanders, Frank McCormick — 1991
• Proteins regulating Ras and its relativesMark S. Boguski, Frank McCormick — 1993
• Biological properties of human c-Ha-ras1 genes mutated at codon 12Peter H. Seeburg, Wendy W. Colby, Daniel J. Capon — 1984
• Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating ProteinsRohit Mittal, Mohammad Reza Ahmadian, Roger S. Goody — 1996
• Aluminium fluoride associates with the small guanine nucleotide binding proteinsMohammad Reza Ahmadian, Rohit Mittal, Alan Hall — 1997
• The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.Klaus Scheffzek, Mohammad Reza Ahmadian, Wolfgang Kabsch — 1997

Cited by

• Role of the Yersinia protein YopK in microbe-host interactionsSara E. Thorslund — 2012
• Analysis of Escherichia coli RecA Interactions with LexA, λ CI, and UmuD by Site-Directed Mutagenesis of recAGeoffrey M. Cooper — 2000
• Trapp Stimulates Guanine Nucleotide Exchange on Ypt1pDoc Searls — 2000
• GTPase catalysis by Ras and other G-proteins: insights from Substrate Directed SuperImposition.Kathleen Meacham — 2003
• Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase*Dennis Fiegen, Lars-Christian Haeusler, Lars Blumenstein — 2004
• Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis理映子 小野, 信子 小川 — 2004
• The Rho family of small GTPases: crucial regulators of skeletal myogenesis信忠 藤井, 元宏 小林, 敏之 牧田 — 2005
• The rab family of small GTPases : structural determinants of lipid modification and functionJ. Leal — 2001
• Rho-GTP binding proteins in Yersinia target cell interaction.Martin Aepfelbacher, Claudia Trasak, Agnès Wiedemann — 2003
• Caractérisation de la RNase E et du dégradosome d'ARN de la bactérie marine adaptée au froid Pseudoalteromonas haloplanktisSoraya Ait-Bara — 2010
• The role for the p85 subunit of PI3kinase in the regulation of rab proteinsJennifer C. King — 2008
• The evolution of small GTP binding proteins in cellular organisms. Studies of RAS GTPases in arabidopsis thaliana and the Ral GTPase from Drosophila melanogasterPer Winge — 2002
• The multifunctional GAP protein YopE of Yersinia is involved in effector translocation control and virulenceElin L. Isaksson — 2010
• The interaction of the p85 subunit of PI3K with rab proteinsM. Dean Chamberlain — 2007
• GTPases in semaphorin signaling.Andreas W. Püschel — 2007
• IQGAP1: A microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity.Ignacio Jausoro, Iván Mestres, M. Virginia Remedi — 2012
• ARF GTPase-activating protein 1.Irit Huber, Edna Cukierman, Miriam Rotman — 2002
• From Unspecific Quenching to Specific Signaling: Functional GTPase Assays Utilizing Quenching Resonance Energy Transfer (QRET) TechnologyKari Kopra — 2015
• Lokalisierung und Funktionsanalyse von Symbiose-relevanten Proteinen der Ackerbohne Vicia faba L.Jörg D. Becker — 2000
• Fusion of Biological Membranes and Related ProblemsH. J. Hilderson, Stephen Fuller — 2002

Related papers

• Mutational analysis of Era, an essential GTP-binding protein of Escherichia coliT Shimamoto — 1996
• Mutational analysis of Era, an essential GTP-binding protein of Escherichia coli.Toshi Shimamoto, Masayori Inouye — 1996
• Real-time in vitro measurement of intrinsic and Ras GAP-mediated GTP hydrolysis.Adam Shutes, Channing J. Der — 2006
• GTP hydrolysis by human tissue transglutaminase homologue.Bassam M. Fraij — 1996
• GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein.Tsung‐Hsien Chuang, Xuemin Xu, Ulla G. Knaus — 1993
• Differential regulation of cellular activities by GTPase-activating protein and NF1Nadia Al-Alawi, Guangwen Xu, R. White — 1993
• The G-protein signaling regulator RGS3 enhances the GTPase activity of KRASChuanchuan Li, Alberto Vides, Dong-Sung Kim — 2021