Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
Explore this paper's citation graph
Summary
The Beta-value has a more intuitive biological interpretation, but the M-value is more statistically valid for the differential analysis of methylation levels, and is recommended for conducting differential methylation analysis and including the beta-value statistics when reporting the results to investigators.
- Type
- article
- Published
- 2010-11-30
- Cited by
- 1,967
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W2056040742
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14780639
Keywords
Methylation, DNA methylation, CpG site, Epigenetics, Computational biology
References
- Array-based DNA methylation profiling in follicular lymphoma
- EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines.
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
- Rat toxicogenomic study reveals analytical consistency across microarray platforms
- Gene silencing in cancer in association with promoter hypermethylation.
- Principles and challenges of genome-wide DNA methylation analysis
- Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip.
- lumi: a pipeline for processing Illumina microarray
- Comprehensive high-throughput arrays for relative methylation (CHARM).
- Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms
- Effects of dependence in high-dimensional multiple testing problems
- Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters
- Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.
- A variance-stabilizing transformation for gene-expression microarray data
- High-throughput DNA methylation profiling using universal bead arrays.
- Model-based variance-stabilizing transformation for Illumina microarray data
- Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
- GoldenGate assay for DNA methylation profiling.
Cited by
- DNA methylation profiling of well‐differentiated thyroid cancer uncovers markers of recurrence free survival
- Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers
- Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value
- Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer
- Transcriptional similarity in couples reveals the impact of shared environment and lifestyle on gene regulation through modified cytosines
- Epigenetic Contribution of the Myosin Light Chain Kinase Gene to the Risk for Acute Respiratory Distress Syndrome
- Novel miRNA-mRNA interactions conserved in essential cancer pathways
- Systemic evaluation of cellular reprogramming processes exploiting a novel R-tool: eegc
- Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood
- Epigenetic dysregulation in adrenocortical carcinoma, a systematic review of the literature.
- Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging
- Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer
- Unraveling the Role of Epigenetics in Aging and Chronic Disease.
- ROLE OF ALLERGIC SENSITIZATION, FILAGGRIN VARIANTS, AND DNA
- The association of DNA methylation patterns in TCF7L2 and GIPR genes with Type 2 Diabetes
- The Effect of High-intensity Interval Training on Maximal Aerobic Capacity, DNA Methylation and Gene Expression in Healthy Elderly Men
- Determination of DNA methylation levels using Illumina HumanMethylation450 BeadChips.
- Computational analysis of CpG site DNA methylation
- Genetic-epigenetic interactions in medulloblastoma development
- Methods for integrative analysis of genomic data
Related papers
- Genetic and environmental impacts on DNA methylation levels in twins.
- DNA methylation in osteoarthritic chondrocytes: a new molecular target.
- Early Nutritional Influences on Human Developmental Epigenetics.
- Changes of DNA methylation of Isoetes sinensis under Pb and Cd stress
- Methylation of CpG sites in BCL2 major breakpoint region and the increase of BCL2/JH translocation with aging
- Distribution of DNA methylation, CpGs, and CpG islands in human isochores.
- Global methylation profiles in DNA from different blood cell types
- Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation
- Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues.