Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

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Summary

The Beta-value has a more intuitive biological interpretation, but the M-value is more statistically valid for the differential analysis of methylation levels, and is recommended for conducting differential methylation analysis and including the beta-value statistics when reporting the results to investigators.

Type
article
Published
2010-11-30
Cited by
1,967
References
26
Access
Open access

Keywords

Methylation, DNA methylation, CpG site, Epigenetics, Computational biology

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