Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging
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Summary
With aging, a decrease in DNAm of cytokines gene CpGs in glia and blood was seen, and additional research is needed to fully elucidate the role of DNAm in aging and how it may influence the pathogenesis of delirium.
- Type
- article
- Published
- 2018-10-23
- Cited by
- 37
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W30405391
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53046412
Keywords
Electroencephalography, Computer science, Brain–computer interface, Artificial intelligence, Linear discriminant analysis
References
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- Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
- Delirium in older persons.
- Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
- Comprehensive Analysis of DNA Methylation Data with RnBeads
- DNA methylation signatures in development and aging of the human prefrontal cortex.
- Age dependent changes in the LPS induced transcriptome of bovine dermal fibroblasts occurs without major changes in the methylome
- Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system.
- Intracisternal interleukin-1 receptor antagonist (IL-1RA) prevents post-operative cognitive decline and neuroinflammatory response in aged rats
- IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344 × BN F1 rats
- Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: A survey of 912 healthcare professionals*
- Spatiotemporal transcriptome of the human brain
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- Differential Immune System DNA Methylation and Cytokine Regulation in Post-Traumatic Stress Disorder
- Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
- Clarifying confusion: the confusion assessment method. A new method for detection of delirium.
- Age-related loss of CpG methylation in the tumour necrosis factor promoter.
Cited by
- Epigenetics biomarkers of delirium: immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients
- DNA methylation change in neurotrophic genes with aging and delirium evidenced from three independent cohorts
- Resistance Training Modulates the Humoral Inflammatory (but Not the DNA Methylation) Profile of Diabetic Older Adults Using Metformin
- Alteration of the brain methylation landscape following postnatal inflammatory injury in rat pups
- Epigenetics of neuroinflammation: immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients
- The relationship between DNA methylation in neurotrophic genes and age as evidenced from three independent cohorts: Differences by delirium status
- Epigenetic Clock: DNA Methylation in Aging
- New Cutoff Scores for Delirium Screening Tools to Predict Patient Mortality
- HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women
- Bispectral EEG (BSEEG) quantifying neuro-inflammation in mice induced by systemic inflammation: A potential mouse model of delirium.
- The Future of Livestock Management: A Review of Real-Time Portable Sequencing Applied to Livestock
- Microglial heterogeneity in aging and Alzheimer's disease: Is sex relevant?
- Biomarkers in delirium: A systematic review.
- Delirium in neurosurgery: a systematic review and meta-analysis
- Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients
- DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium
- Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation
- Epigenetics of post-operative delirium: A genome-wide DNA methylation study of neurosurgery patients
- Genome-wide DNA methylation analysis of post-operative delirium with brain, blood, saliva, and buccal samples from neurosurgery patients
- The genome-wide DNA methylation profiles among neurosurgery patients with and without post-operative delirium
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