DNA methylation in osteoarthritic chondrocytes: a new molecular target.
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Summary
Early evidence points to a role of epigenetics in the pathogenesis of OA, and epigenetic changes, although heritable at the cellular level, are potentially reversible, could be a new molecular target for therapeutic intervention, especially early in the disease.
- Type
- review
- Published
- 2007-02-01
- Cited by
- 89
- References
- 83
- Access
- Open access
- OpenAlex
- https://openalex.org/W2073893804
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20351732
Keywords
Epigenetics, DNA methylation, Biology, Methylation, Epigenetics of physical exercise
References
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- MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage.
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- The role of cytokines in osteoarthritis pathophysiology
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- Aggrecanases and cartilage matrix degradation
- Expression of various genes is controlled by DNA methylation during mammalian development
Cited by
- New molecular targets for the treatment of osteoarthritis.
- The role of histone deacetylases in cartilage gene regulation and chondroprotection
- Régulation transcriptionnelle du gène HSPG2 codant pour Perlecan et son implication dans l’ostéoarthrite
- The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine
- DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter
- КЛИНИЧЕСКАЯ ЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ПРИМЕНЕНИЯ АГОНИСТОВ РЕЦЕПТОРОВ, АКТИВИРУЕМЫХ ПЕРОКСИСОМНЫМ ПРОЛИФЕРАТОРОМ АЛЬФА, У БОЛЬНЫХ РЕВМАТОИДНЫМ АРТРИТОМ: ОТКРЫТОЕ КОНТРОЛИРУЕМОЕ ИССЛЕДОВАНИЕ
- Improved Quantification of DNA Methylation Using Methylation-Sensitive Restriction Enzymes and Real-Time PCR
- Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis.
- Mechanical and biologic link between cartilage and subchondral bone in osteoarthritis
- The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes – Implications for osteoarthritis
- Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells.
- Loss of Methylation in CpG Sites in the NF-κB Enhancer Elements of Inducible Nitric Oxide Synthase Is Responsible for Gene Induction in Human Articular Chondrocytes
- Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites*
- Two non-coding RNAs, MicroRNA-101 and HOTTIP contribute cartilage integrity by epigenetic and homeotic regulation of integrin-α1.
- The Role of DNA Methylation in Common Skeletal Disorders
- Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage
- Drug Insight: aggrecanases as therapeutic targets for osteoarthritis
- Therapeutic targets for osteoarthritis.
- Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis
- Mseleni joint disease: a potential model of epigenetic chondrodysplasia.
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