A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA
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Summary
In Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let-7 stRNA, which regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals.
- Type
- article
- Published
- 2001-07-12
- Cited by
- 2,950
- References
- 12
- OpenAlex
- https://openalex.org/W2054109341
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6177608
Keywords
Dicer, RNA interference, RNA, RNA silencing, Biology
References
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- RNA interference is mediated by 21- and 22-nucleotide RNAs.
- Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.
- Incorporation of terminal phosphorothioates into oligonucleotides.
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- A Biochemical Dissection of the RNA Interference Pathway in Drosophila melanogaster : A Dissertation
- RARs and microRNAs.
- Gene expression: Dicing with development
- RNA Interference and Development
- Gene expression regulators —MicroRNAs
- microRNAs in Cancer: biological effects of microRNAs in colorectal cancer
- RNA interference for treating cancers caused by viral infection
- Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells
- Designing efficient and specific endoribonuclease-prepared siRNAs.
- MicroRNA genes are transcribed by RNA polymerase II
- Cell cycle regulation by microRNAs in stem cells.
- Nuclear export of RNA
- Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha
- Use of RNA polymerase II to transcribe artificial microRNAs.
- The Conserved FRNK Box in HC-Pro, a Plant Viral Suppressor of Gene Silencing, Is Required for Small RNA Binding and Mediates Symptom Development
- Translational Medicine: microRNAs: a new emerging class of players for disease diagnostics and gene therapy
- MicroRNAs in breast cancer
- TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.
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