Mechanisms of gene silencing by double-stranded RNA
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Summary
A key step in known silencing pathways is the processing of dsRNAs into short RNA duplexes of characteristic size and structure, which guide RNA silencing by specific and distinct mechanisms.
- Type
- review
- Published
- 2004-09-15
- Cited by
- 2,592
- References
- 103
- OpenAlex
- https://openalex.org/W1989454102
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:90438
Keywords
RNA silencing, RNA-induced silencing complex, RNA-induced transcriptional silencing, Trans-acting siRNA, Gene silencing
References
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- RNA Silencing Genes Control de Novo DNA Methylation
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- Epigenetics--gene silencing.
- A Biochemical Dissection of the RNA Interference Pathway in Drosophila melanogaster : A Dissertation
- Characterization of RNAi-defective mutants -- Mut13-2 and Mut20 -- in Chlamydomonas reinhardtii
- Optimization of transfection conditions and analysis of siRNA potency using real-time PCR.
- Epigenetic manipulation of gene expression
- RNA meets chromatin.
- The role of enterovirus in chronic fatigue syndrome
- RNA knockdown as a potential therapeutic strategy in Parkinson's disease
- XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells.
- OligoMatcher: analysis and selection of specific oligonucleotide sequences for gene silencing by antisense or siRNA.
- Interferon action and the double-stranded RNA-dependent enzymes ADAR1 adenosine deaminase and PKR protein kinase.
- siRNA design principles and off-target effects.
- In vitro precursor microRNA processing assays using Drosophila Schneider-2 cell lysates.
- Therapeutic RNA interference for neurodegenerative diseases: From promise to progress.
- Sequence‐specific inhibition of RNA polymerase III‐dependent transcription using Zorro locked nucleic acid (LNA)
- RNA interference to target lipid disorders
- Enzymatic Incorporation of Emissive Pyrimidine Ribonucleotides
- Production of double-stranded RNA for interference with TMV infection utilizing a bacterial prokaryotic expression system
- Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat.
- RNA interference with 2',4'-bridged nucleic acid analogues.
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