TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.
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Summary
The role of TUT4 and Lin28 are uncovers as specific suppressors of miRNA biogenesis, which has implications for stem cell research and cancer biology.
- Type
- article
- Published
- 2009-08-21
- Cited by
- 839
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W19703396
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15469064
Keywords
Medicine, Gynecology
References
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- let-7 microRNAs in development, stem cells and cancer.
- Selective Blockade of MicroRNA Processing by Lin28
- Research Communication
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- Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation
- Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28*
- Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
- Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.
- Human embryonic stem cells express a unique set of microRNAs.
Cited by
- Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer
- pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5′/3′ arm variation including concomitant cleavage and polyuridylation patterns
- Functional implications from the Cid1 poly(U) polymerase crystal structure.
- Competition and collaboration between RNA‐binding proteins and microRNAs
- Emerging roles of RNA modification: m(6)A and U-tail.
- Polyuridylation in Eukaryotes: A 3′-End Modification Regulating RNA Life
- Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner
- Tipping the balance of RNA stability by 3' editing of the transcriptome.
- Stress-induced changes in miRNA biogenesis and functioning
- Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment.
- MicroRNA biogenesis and cancer.
- Probing microRNA Activity in vitro and inside Cells using Single Molecule Microscopy.
- Processing, stability and RNA editing of microRNAs in Xenopus oocytes and eggs
- Pluripotency and genetic stability of human pluripotent stem cells
- MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation.
- let-7 MicroRNAs Induce Tamoxifen Sensitivity by Downregulation of Estrogen Receptor α Signaling in Breast Cancer
- The regulation of microRNA biogenesis by ribosome-interacting proteins
- Regulation of pre-miRNA processing.
- Let's make it happen: the role of let-7 microRNA in development.
- Let7a involves in neural stem cell differentiation relating with TLX level.
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