Understanding the odd science of aging.
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Summary
To understand the cell and molecular basis of aging is to unravel the multiplicity of mechanisms causing damage to accumulate and the complex array of systems working to keep damage at bay.
- Type
- review
- Published
- 2005-02-25
- Cited by
- 1,969
- References
- 77
- Access
- Open access
- OpenAlex
- https://openalex.org/W2054059225
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7514614
Keywords
Biology, Somatic cell, Evolutionary biology, Hazard, Ecology
References
- DNA repair and the evolution of longevity: a critical analysis.
- Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease
- Altered stem cell regeneration in irradiated intestinal crypts of senescent mice.
- Neuropathological and Histochemical Changes in a Multiple Mitochondrial DNA Deletion Disorder
- Chance, development, and aging
- Aging and molecular chaperones.
- Longevity, senescence, and the genome
- The natural regulation of animal numbers
- Aging, tumor suppression and cancer: high wire-act!
- Why do we age?
- Handbook of the Biology of Aging
- Genetic pathways that regulate ageing in model organisms
- Physiology and pathophysiology of poly(ADP‐ribosyl)ation *
- Evolution of human longevity and the genetic complexity governing aging rate.
- Toward reconciling inferences concerning genetic variation in senescence in Drosophila melanogaster.
- Replicative senescence and the art of counting.
- What Can Progeroid Syndromes Tell Us About Human Aging?
- Epigenetic regulation of aging in honeybee workers.
- Insulin/IGF signalling and ageing: seeing the bigger picture.
- Age changes in stem cells of murine small intestinal crypts.
Cited by
- Rapid neonatal weight gain in rats results in a renal ubiquinone (CoQ) deficiency associated with premature death.
- Premature aging in mice activates a systemic metabolic response involving autophagy induction.
- Phenotypic plasticity and longevity in plants and animals: cause and effect?
- Can biogerontologists and geriatricians unite to apply aging science to health care in the decade ahead?
- Wie die Sonne unsere Haut altern lässt
- An aging program at the systems level?
- Senescing human bone-marrow-derived clonal mesenchymal stem cells have altered lysophospholipid composition and functionality.
- Human cognitive aging: Corriger la fortune?
- Why Is Aging Conserved and What Can We Do about It?
- Answering the ultimate question “What is the Proximal Cause of Aging?”
- Effect of aging on stem cells
- Shifts in rotifer life history in response to stable isotope enrichment: testing theories of isotope effects on organismal growth
- Quantitative sensory testing in elderly: longitudinal study
- Telomere maintenance during anterior regeneration and aging in the freshwater annelid Aeolosoma viride
- Causes and Consequences of Mitochondrial Variation in Caenorhabditid Nematodes
- Lithocholic Acid and Macromitophagy Regulate the Dynamics of Lipid Metabolism and Storage to Modulate Chronological Aging in Saccharomyces cerevisiae
- Insulin signaling, dietary restriction and DNA damage: Multiple roles for smk-1 in the mediation of C. elegans life span
- Using the Experimental Evolution of Long-Lived Yeast Species for Testing Evolutionary Theories of Aging
- Autophagy and aging: lessons from progeria models.
- Microglia in the aging retina.
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