Nutrient Signaling to mTOR and Cell Growth
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Summary
The mammalian target of rapamycin (mTOR) is a conserved protein kinase involved in a multitude of cellular processes including cell growth and inhibition of mTOR has proven efficacious in numerous clinical trials.
- Type
- review
- Published
- 2013-03-01
- Cited by
- 394
- References
- 95
- Access
- Open access
- OpenAlex
- https://openalex.org/W2051648135
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27189430
Keywords
mTORC1, mTORC2, PI3K/AKT/mTOR pathway, Mechanistic target of rapamycin, Biology
References
- Rheb promotes cell growth as a component of the insulin/TOR signalling network
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy*
- The mTOR Signalling Pathway in Human Cancer
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR
- The translational landscape of mTOR signalling steers cancer initiation and metastasis
- Regulation of mTORC1 by the Rab and Arf GTPases*
- Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
- TSC1 Stabilizes TSC2 by Inhibiting the Interaction between TSC2 and the HERC1 Ubiquitin Ligase*
- TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
- Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes
- Identification and characterization of a lysosomal transporter for small neutral amino acids
- mTOR signaling: PLD takes center stage
- Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency*
- An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1
- Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy
- Glutaminolysis activates Rag-mTORC1 signaling.
- GEFs and GAPs: critical elements in the control of small G proteins.
- Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.
- Leucyl-tRNA synthetase controls TORC1 via the EGO complex.
Cited by
- Seh1 targets GATOR2 and Nup153 to mitotic chromosomes
- Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
- Cell cycle regulation by the nutrient-sensing mammalian target of rapamycin (mTOR) pathway.
- Elevated Oxygen Consumption Rate in Response to Acute Low- Glucose Stress: Metformin Restores Rate to Normal Level
- Disruption of the Rag-Ragulator complex by c17orf59 inhibits mTORC1
- The influence of mechanical loading on skeletal muscle protein turnover
- Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascade
- Reconstructing The S. Cerevisiae Growth Control Network In Stress Conditions
- Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting
- Autophagy in renal diseases
- Genetics and pharmacology of longevity: the road to therapeutics for healthy aging.
- Elucidating The Regulatory Mechanisms Of The Mammalian Target Of Rapamycin Complex 1 (Mtorc1) In Protein Homeostasis
- S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation
- Identification of microRNAs regulating adipocyte differentiation via mTOR nutrient-signaling
- mTOR in health and in sickness
- Autophagy protects intestinal epithelial cells against deoxynivalenol toxicity by alleviating oxidative stress via IKK signaling pathway.
- Studies on the response to, and recovery from, rapamycin in Saccharomyces cerevisiae
- The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila
- mTORC1 signaling controls multiple steps in ribosome biogenesis.
- Radiolabeled Amino Acids for Oncologic Imaging
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- Data from TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
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