Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
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Summary
It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
- Type
- article
- Published
- 2006-04-21
- Cited by
- 2,833
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1983698019
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11593910
Keywords
mTORC2, Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell biology
References
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- Mechanism of activation of protein kinase B by insulin and IGF‐1.
- Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells.
- Negative Regulation of the Forkhead Transcription Factor FKHR by Akt*
- Structure of S6 Kinase 1 Determines whether Raptor-mTOR or Rictor-mTOR Phosphorylates Its Hydrophobic Motif Site*♦
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- An expanding role for mTOR in cancer.
- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
- Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.
- Sirolimus changes lipid concentrations and lipoprotein metabolism in kidney transplant recipients.
- Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.
- Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
- The impact of Sirolimus Eluting stents in interventional cardiology.
- RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
- Clinical application of sirolimus in renal transplantation: an update
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- Primary resistance to ATP-competitive mTOR inhibitors for the treatment of solid tumors
- Proteins affecting rod photoreceptor differentiation in the murine retina: A proteomics approach with emphasis on mTOR
- Therapeutic targets: MTOR and related pathways
- An improved bioluminescence resonance energy transfer strategy for imaging intracellular events in single cells and living subjects.
- Phase I study of everolimus in pediatric patients with refractory solid tumors.
- mTOR in Growth and Protection of Hypertrophying Myocardium
- Phospho-p70S6K/p85S6K and cdc2/cdk1 Are Novel Targets for Diffuse Large B-Cell Lymphoma Combination Therapy
- Phosphatidylinositol 3-kinase (PI3K): The Oncoprotein
- Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt
- Contribution of PKB/AKT signaling to thyroid cancer.
- Direct activation of mTOR in B lymphocytes confers impairment in B‐cell maturation andloss of marginal zone B cells
- Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis
- Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs
- Evaluation of rapamycin-induced cell death.
- Regulation of TOR by small GTPases
- The FKBP-rapamycin binding domain of human TOR undergoes strong conformational changes in the presence of membrane mimetics with and without the regulator phosphatidic acid.
- Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: pharmacokinetic considerations and clinical implications.
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