Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
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Summary
The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
- Type
- article
- Published
- 2002-06-17
- Cited by
- 2,192
- References
- 43
- OpenAlex
- https://openalex.org/W2049965571
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11573586
Keywords
Adiponectin, Endocrinology, Internal medicine, Insulin resistance, Adipose tissue
References
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- Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
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- Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
- The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor.
- A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)
- Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.
Cited by
- Non-alcoholic fatty liver disease (NAFLD) in children.
- Low plasma adiponectin concentrations do not predict weight gain in humans.
- The metabolic syndrome, inflammation and cardiovascular disease in type 2 diabetes.
- Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome
- Regulation of adiponectin receptor gene expression in diabetic mice.
- Association between dietary factors and plasma adiponectin concentrations in men.
- Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
- The relationships of plasma adiponectin with a favorable lipid profile, decreased inflammation, and less ectopic fat accumulation depend on adiposity.
- Lack of synergistic effects of metabolic syndrome and plasma fibrinogen on coronary events and mortality in moderate CKD.
- Pathogenesis of non-alcoholic steatohepatitis: human data.
- Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats
- Adiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-&agr;
- Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet.
- Novel mutation in the adiponectin (ADIPOQ) gene is associated with hypoadiponectinaemia in Japanese–Brazilians
- The role of insulin resistance in the pathogenesis of atherosclerotic cardiovascular disease: an updated review
- Adiponectin as a biomarker of the metabolic syndrome in children and adolescents
- Adiponectin and the control of female reproductive functions.
- Decoding Insulin Resistance and Metabolic Syndrome for Promising Therapeutic Intervention
- Adipose Tissue Immune Response: Novel Triggers and Consequences for Chronic Inflammatory Conditions
- Restoration of adiponectin expression via the ERK pathway in TNFα-treated 3T3-L1 adipocytes.
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