Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
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Summary
A role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance is suggested as well as the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA.
- Type
- article
- Published
- 1995-05-01
- Cited by
- 3,770
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974033843
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14488702
Keywords
Adipose tissue, Insulin resistance, Endocrinology, Internal medicine, Hyperinsulinemia
References
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- Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
- Altered Immune Function in a Morbidly Obese Pediatric Population a
- Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.
- In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects.
- Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.
- Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline.
- Insulin-Receptor Autophosphorylation and Endogenous Substrate Phosphorylation in Human Adipocytes From Control, Obese, and NIDDM Subjects
- Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.
- Tumor necrosis factor (TNF).
- Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
- Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
- Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
- Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.
- The biology of cachectin/TNF--a primary mediator of the host response.
- Insulin resistance--mechanisms, syndromes, and implications.
- Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.
- Epidemiology of diabetes mellitus.
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- Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome
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- Role of Inflammation in Diet-Induced Obesity: A Dissertation
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- Non-insulin-dependent diabetes mellitus--a collision between thrifty genes and an affluent society.
- Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF-alpha?
- The role of cytokines in cancer cachexia
- Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness
- Oxidative Stress in the Pathogenesis of Preeclampsia (44447)
- Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha.
- Preperitoneal fat thickness determined by ultrasonography is correlated with coronary stenosis and lipid disorders in non-obese male subjects
- Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture.
- Genetics of the metabolic syndrome
- Evaluation of factors during OGTT to correlate insulin resistance in non-diabetic subjects.
- The role of fat depletion in the biological benefits of caloric restriction.
- Genetic variation in the stress protein hsp70-2 gene is highly associated with obesity
- Gene expression in visceral and subcutaneous adipose tissues
- Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.
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