Insulin signalling and the regulation of glucose and lipid metabolism
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Summary
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide, and tissues such as muscle, fat and liver become less responsive or resistant to insulin.
- Type
- article
- Published
- 2001-12-13
- Cited by
- 5,421
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W2014887370
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1119157
Keywords
Insulin resistance, Insulin, Endocrinology, Internal medicine, Type 2 diabetes
References
- Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
- Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
- Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase
- Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
- The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
- Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α
- The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
- Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
- The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
- The lipid phosphatase SHIP2 controls insulin sensitivity
- Disruption of IRS-2 causes type 2 diabetes in mice
- Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes.
- Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
- Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.
- Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase.
- Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway*
- ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
- Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes
- Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes
- Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.
Cited by
- Estrès del reticle endoplasmàtic, inflamació i resistència a la insulina en cèl•lules musculars esquelètiques
- Resitin and adiponectin in the Bahraini population : plasma levels, gene polymorphisms and their association with type 2 diabetes and related metabolic parameters.
- Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome
- Hormonal regulation of ATP binding cassette transporters
- Identifying risk of type 2 diabetes : epidemiologic perspectives from biomarkers to lifestyle
- Role of Inflammation in Diet-Induced Obesity: A Dissertation
- Inositol phosphates and phosphoinositides in health and disease.
- Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice
- Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
- The polycystic ovary syndrome: what does insulin resistance have to do with it?
- Insulin-Like Growth Factor-1 Receptor Activation Inhibits Oxidized LDL-Induced Cytochrome C Release and Apoptosis via the Phosphatidylinositol 3 Kinase/Akt Signaling Pathway
- Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
- PPARγ as a metabolic regulator: insights from genomics and pharmacology
- Das metabolische Syndrom
- Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat.
- Effect of food restriction on the insulin signalling pathway in rat skeletal muscle and adipose tissue.
- Association of the promoter polymorphism −232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus
- Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
- Sphingomyelin and its role in cellular signaling.
- Glucotoxicity in the INS-1 Rat Insulinoma Cell Line Is Mediated by the Orphan Nuclear Receptor Small Heterodimer Partner
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