Small RNA asymmetry in RNAi: Function in RISC assembly and gene regulation
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Summary
The rules of the asymmetric RISC formation are reviewed and their possible regulatory function in several steps in RNAi is discussed.
- Type
- review
- Published
- 2005-10-31
- Cited by
- 206
- References
- 95
- Access
- Open access
- OpenAlex
- https://openalex.org/W2049772182
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13952332
Keywords
RNA interference, RNA-induced silencing complex, RNA silencing, Effector, Gene silencing
References
- MicroRNA genes are transcribed by RNA polymerase II
- Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha
- Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning.
- RNA interference is required for normal centromere function infission yeast
- Diverse roles for RNA in gene regulation
- Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
- Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
- Variation in the reversibility of evolution
- SDE3 encodes an RNA helicase required for post‐transcriptional gene silencing in Arabidopsis
- The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification.
- Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs.
- Vertebrate MicroRNA Genes
- DICER-LIKE1: blind men and elephants in Arabidopsis development.
- Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
- Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway.
- The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter.
- c-Myc-regulated microRNAs modulate E2F1 expression
- Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
- The nuclear RNase III Drosha initiates microRNA processing
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- Stretch-Induced Effects on MicroRNA Expression and Exogenous MicroRNA Delivery in Differentiating Skeletal Myoblasts
- Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer
- Adenoviral Control of RNAi/miRNA Pathways in Human Cells
- siRNA Targeting of Thymidylate Synthase, Thymidine Kinase 1 and Thymidine Kinase 2 as an Anticancer Therapy: A Combinatorial RNAi Approach
- ROLE OF MICRO RNA 148/152 FAMILY IN CANCER PROGRESSION
- MOLECULAR MECHANISMS OF RADIATION-INDUCED BYSTANDER EFFECTS IN VIVO
- Expression, transkriptionelle Regulation und biologische Funktion des humanen Arylhydrokarbon Rezeptor Repressors
- Functional Investigation of the ATPase/Helicase Domain of Human Dicer
- MicroRNA Expression Profile in Bovine Granulosa Cells of Preovulatory Dominant and Subordinate Follicles during the Late Follicular Phase of the Estrous Cycle
- Identification and characterisation of MORC6 as a component of the RNA-directed DNA methylation pathway in Arabidopsis thaliana
- Bedeutung der miRNA-21 für die Pathogenese der atrialen Fibrose und Vorhofflimmern
- Cloning and characterization of microRNAs from Brassica napus
- Diversity and host interactions of emerging tomato begomoviruses in Brazil
- Application of RNAi to silence tartrate-resistant acid phosphatase: unexpected effects on the monocyte-macrophage lineage
- Mechanism(s) by which pigment epithelium-derived factor regulate angiogenesis
- Bayesian Analysis for miRNA and mRNA Interactions Using Expression Data
- Prediction and characterization of novel microRNAs from brown plant hopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae)
- The Multiple Roles of Microrna-223 in Regulating Bone Metabolism
- Designing Highly Active siRNAs for Therapeutic Applications
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