Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

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Summary

These results suggest that metazoan miRNAs can reduce the levels of many of their target transcripts, not just the amount of protein deriving from these transcripts, and seem to downregulate a far greater number of targets than previously appreciated.

Type
article
Published
2005-02-17
Cited by
4,972
References
41

Keywords

microRNA, Biology, Messenger RNA, Gene expression, DNA microarray

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