Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
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Summary
These results suggest that metazoan miRNAs can reduce the levels of many of their target transcripts, not just the amount of protein deriving from these transcripts, and seem to downregulate a far greater number of targets than previously appreciated.
- Type
- article
- Published
- 2005-02-17
- Cited by
- 4,972
- References
- 41
- OpenAlex
- https://openalex.org/W1978337436
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4430576
Keywords
microRNA, Biology, Messenger RNA, Gene expression, DNA microarray
References
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- A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons.
- miRNAs in cancer: approaches, aetiology, diagnostics and therapy.
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