Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction*
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Summary
It is demonstrated that TLR4 is involved in lipopolysaccharide signaling and serves as a cell-surface co-receptor for CD14, leading to lipopoly Saccharide-mediated NF-κB activation and subsequent cellular events.
- Type
- article
- Published
- 1999-04-16
- Cited by
- 2,084
- References
- 22
- Access
- Open access
- OpenAlex
- https://openalex.org/W2049197565
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21900864
Keywords
Signal transduction, Toll-like receptor, Lipopolysaccharide, Receptor, Cell biology
References
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Cited by
- Innate immunity: Lipoproteins take their Toll on the host
- cAMP induces CD14 expression in murine macrophages via increased transcription
- Endotoxin responsiveness and subchronic grain dust-induced airway disease.
- Role of Toll-Like Receptors in Changes in Gene Expression and NF-κB Activation in Mouse Hepatocytes Stimulated with Lipopolysaccharide
- Lipopolysaccharide-Induced Leukocyte-Endothelial Cell Interactions: A Role for CD14 Versus Toll-Like Receptor 4 Within Microvessels1
- Evaluation of toll-like receptor 4 gene expression of immortalized human liver cell lines.
- Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors*
- Injury, sepsis, and the regulation of Toll‐like receptor responses
- Differentiation-regulated expression of Toll-like receptors 2 and 4 in HaCaT keratinocytes
- Disruption of MAP kinase activation and nuclear factor binding to the IL‐12 p40 promoter in HIV‐infected myeloid cells
- Imaging analysis of STAT1 and NF-kappaB translocation in dendritic cells at the single cell level.
- Pseudomonas aeruginosa: Role in the Pathogenesis of the CF Lung Lesion
- Toll-like Receptor 4 Region Glu24–Lys47 Is a Site for MD-2 Binding
- Pivotal Involvement of Fcγ Receptor IIA in the Neutralization of Lipopolysaccharide Signaling via a Potent Novel Anti-TLR4 Monoclonal Antibody 15C1*
- Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.
- Meconium-induced release of cytokines is mediated by the TRL4/MD-2 complex in a CD14-dependent manner.
- Glial and neuroinflammatory targets for treating substance use disorders
- Presentation matters: Impact of association of amphiphilic LPS with serum carrier proteins on innate immune signaling
- Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway
- Lack of interferon response in animals to naked siRNAs
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