Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt
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Summary
Findings suggest that in the developing nervous system, Akt is a critical mediator of growth factor-induced neuronal survival.
- Type
- article
- Published
- 1997-01-31
- Cited by
- 2,571
- References
- 43
- OpenAlex
- https://openalex.org/W2048121649
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7658844
Keywords
P70-S6 Kinase 1, Protein kinase B, Ribosomal s6 kinase, PI3K/AKT/mTOR pathway, Cell biology
References
- Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase.
- The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential.
- Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli.
- The insulin signaling system.
- Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism
- Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants.
- AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
- Inhibition of p38 Mitogen-activated Protein Kinase by Insulin in Cultured Fetal Neurons (*)
- PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
- Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.
- Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
- ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK.
- Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras
- A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
- The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.
- Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.
- The insulin‐like growth factor I system in the rat cerebellum: Developmental regulation and role in neuronal survival and differentiation
- Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.
- Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons.
- Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice.
Cited by
- Survival factors and apoptosis.
- A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis
- Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
- Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line
- The Activation of p38 and Apoptosis by the Inhibition of Erk Is Antagonized by the Phosphoinositide 3-Kinase/Akt Pathway*
- Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt
- Phosphoinositide kinases and the synthesis of polyphosphoinositides in higher plant cells.
- bFGF inhibits the activation of caspase-3 and apoptosis of P19 embryonal carcinoma cells during neuronal differentiation
- Impact of neonatal kainate treatment on hippocampal insulin-like growth factor receptors.
- Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia.
- Activation of Akt is induced by heat shock and involved in suppression of heat-shock-induced apoptosis of NIH3T3 cells.
- Epidermal Growth Factor Receptor-dependent Control of Keratinocyte Survival and Bcl-xL Expression through a MEK-dependent Pathway*
- Regulation of the PRL promoter by Akt through cAMP response element binding protein.
- Signaling Events in Amyloid β-Peptide-induced Neuronal Death and Insulin-like Growth Factor I Protection*
- Neuroprotection by scatter factor/hepatocyte growth factor and FGF‐1 in cerebellar granule neurons is phosphatidylinositol 3‐kinase/Akt‐dependent and MAPK/CREB‐independent
- The Role of Asp-462 in Regulating Akt Activity*
- Pyrrolidine dithiocarbamate‐induced neuronal cell death is mediated by Akt, casein kinase 2, c‐Jun N‐terminal kinase, and IκB kinase in embryonic hippocampal progenitor cells
- Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1.
- Insulin-Like Growth Factor-1 Receptor Activation Inhibits Oxidized LDL-Induced Cytochrome C Release and Apoptosis via the Phosphatidylinositol 3 Kinase/Akt Signaling Pathway
- Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells
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