The machinery of macroautophagy
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Summary
This review focuses on macroautophagy, briefly describing the discovery of this process in mammalian cells, discussing the current views concerning the donor membrane that forms the phagophore, and characterizing the autophagy machinery including the available structural information.
- Type
- review
- Published
- 2013-12-24
- Cited by
- 1,952
- References
- 184
- Access
- Open access
- OpenAlex
- https://openalex.org/W2044621729
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2422872
Keywords
Autophagy, Autophagosome, Biology, Cell biology, Lysosome
References
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- Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases
- A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy
Cited by
- Autophagy in Vascular Disease
- Differential autophagic responses to nano-sized materials.
- Avoidance and subversion of eukaryotic homeostatic autophagy mechanisms by bacterial pathogens
- Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells.
- Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases
- Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation
- Lipid droplet autophagy during energy mobilization, lipid homeostasis and protein quality control
- Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation
- CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans
- HSV-TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK
- The Endolysosomal System and Proteostasis: From Development to Degeneration
- The Pat1-Lsm complex stabilizes ATG mRNA during nitrogen starvation-induced autophagy
- Diverse Functions of Autophagy in Liver Physiology and Liver Diseases
- Effet de la composition en macronutriments de l’aliment sur les mécanismes de contrôle de l’autophagie chez la truite arc-enciel (Oncorhynchus mykiss)
- Targeted Knockout of Beclin-1 Reveals an Essential Function in Ovary and Testis
- Autophagy in glaucoma: Crosstalk with apoptosis and its implications.
- Analysis of human protein complexes by quantitative mass spectrometry
- Age-regulated function of autophagy in the mouse inner ear.
- A Role for Macro-ER-Phagy in ER Quality Control
- Manipulation of host cell death and innate immune signaling pathways by Coxsackievirus B3
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