The landscape of cancer genes and mutational processes in breast cancer
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Summary
Strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade are found, and multiple mutational signatures are observed, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides.
- Type
- article
- Published
- 2012-05-16
- Cited by
- 1,742
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W1979946545
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4341255
Keywords
Biology, Breast cancer, Genetics, Gene, Cancer
References
- Oncogenic transformation and experimental models of human cancer.
- Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.
- Tbx3 improves the germ-line competency of induced pluripotent stem cells
- Statistical Analysis of Pathogenicity of Somatic Mutations in Cancer
- Akt (Protein Kinase B) Negatively Regulates SEK1 by Means of Protein Phosphorylation*
- Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
- Molecular Analysis of the P27/Kip1 Gene in Breast Cancer
- Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology
- Allele-specific copy number analysis of tumors
- The functional Interactions Between the MAPK and p53 Signaling Pathways
- Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects
- A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
- Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
- On the nature of susceptibility to cancer. The presidential address
- Patterns of somatic mutation in human cancer genomes
- Signalling Pathways Implicated in Early Mammary Gland Morphogenesis and Breast Cancer
- ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
- The SWI/SNF complex and cancer
- Differential recruitment of nuclear receptor coregulators in ligand-dependent transcriptional repression by estrogen receptor-α
- The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Cited by
- Statistical methods for robust analysis of transcriptome data by integration of biological prior knowledge
- Advances in the treatment of luminal breast cancer
- Targeting the PyMT Oncogene to Diverse Mammary Cell Populations Enhances Tumor Heterogeneity and Generates Rare Breast Cancer Subtypes.
- Targeting the PI3-kinase/Akt/mTOR Signaling Pathway
- Epidemiology of breast cancer.
- Integration of Genomic Data Enables Selective Discovery of Breast Cancer Drivers
- Cell signaling events differentiate ER-negative subtypes from ER-positive breast cancer
- Targeted therapies for ER+/HER2- metastatic breast cancer
- Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance
- Somatic TP53 Mutations in the Era of Genome Sequencing.
- Identifying Cancer Driver Genes Using Replication-Incompetent Retroviral Vectors
- Mutant PIK3CA Induces EMT in a Cell Type Specific Manner
- Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution
- Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage
- Clinical and Therapeutic Implications of Histone Acetylation in Breast Cancer.
- Sequencing a super multiple synchronous lung cancer reveals a novel variant in driver gene ARID1B
- Unraveling the role of low‐frequency mutated genes in breast cancer
- Genomic Alterations Associated with Recurrence and TNBC Subtype in High-Risk Early Breast Cancers
- Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy
- Breast Cancer Heterogeneity in Primary and Metastatic Disease.
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