The clonal evolution of tumor cell populations.
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Summary
Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
- Type
- article
- Published
- 1976-10-01
- Cited by
- 6,597
- References
- 52
- OpenAlex
- https://openalex.org/W1967304777
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38445059
Keywords
clone (Java method), Biology, Tumor cells, Somatic evolution in cancer, Neoplasm
References
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Cited by
- Metastasis results from preexisting variant cells within a malignant tumor.
- Colorectal adenoma and cancer divergence. Evidence of multilineage progression.
- Expression of carcinoembryonic antigen and ferritin in normal, hyperplastic, and neoplastic endometrium.
- Molecular oncogenetics of metastasis.
- High levels of chromosome instability in polyploids of Saccharomyces cerevisiae.
- Clustering of discrete cell properties essential for tumorigenicity and metastasis. II. Studies of syrian hamster embryo fibroblasts transformed by rous sarcoma virus
- The expression of anchorage independence by malignant rat oral keratinocytes after colony formation in vitro and tumour formation in vivo.
- The sequential development of cancer: a morphological perspective.
- Clonal changes in tumours during growth and progression evaluated by southern gel analysis of random integrations of foreign DNA.
- Survival in breast cancer diagnosed between mammographic screening examinations.
- Molecular genetic characterization of CNS tumor oncogenesis.
- On the clonal origin of tumors: A review of experimental models
- Enhancement of experimental metastasis by pretreatment of tumour cells with hydroxyurea
- Mathematical models of cell variation seen in a heterogeneous malignant cell population.
- Fundamental Conditions for the Evolution of Altruism: Towards a Unification of Theories
- N-linked oligosaccharides and metastatic propensity in in vivo selected mouse mammary adenocarcinoma cells
- Melanin production in a medullary thyroid carcinoma
- Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. VI. Occasional escape from host rejection due to antigen‐loss secondary variants
- Cancer metastasis: Organ colonization and the cell-surface properties of mallignant cells
- Stem Cell Origin of Cell Lineages, Proliferative Units, and Cancer in the Gastrointestinal Tract
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