Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
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Summary
The results suggest that itching during inflammatory skin diseases such as atopic dermatitis is linked to a distinct itch-generating type, and demonstrate single-cell RNA-seq as an effective strategy for dissecting sensory responsive cells into distinct neuronal types.
- Type
- article
- Published
- 2014-11-24
- Cited by
- 1,934
- References
- 60
- OpenAlex
- https://openalex.org/W2033072655
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205437148
Keywords
Sensory system, Cell type, Neuroscience, Biology, Mechanosensitive channels
References
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- Bayesian approach to single-cell differential expression analysis
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- New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?
- TRPM3 is a nociceptor channel involved in the detection of noxious heat.
- The Transcription Factor c-Maf Controls Touch Receptor Development and Function
- Identification of a cold receptor reveals a general role for TRP channels in thermosensation
- The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons.
- Piezo1 and Piezo2 are essential components of distinct mechanically-activated cation channels
- [Research on the fine-structure of spinal ganglia].
- Sphingosine-1-phosphate receptors as emerging targets for treatment of pain.
- Generation of somatic sensory neuron diversity and implications on sensory coding
- Highly multiplexed and strand-specific single-cell RNA 5′ end sequencing
- Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets.
Cited by
- SINCERA: A Pipeline for Single-Cell RNA-Seq Profiling Analysis
- Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
- Single cell RNA sequencing of stem cell-derived retinal ganglion cells
- Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
- Review: Genomic mosaicism in the developing and adult brain
- Lysophosphatidic acid activates satellite glia cells and Schwann cells
- Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain
- Neuronal Subtype and Satellite Cell Tropism Are Determinants of Varicella-Zoster Virus Virulence in Human Dorsal Root Ganglia Xenografts In Vivo
- Geometry of the Gene Expression Space of Individual Cells
- The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain
- Afferent hyperexcitability in neuropathic pain and the inconvenient truth about its degeneracy.
- Defining Mononuclear Phagocyte Subset Homology Across Several Distant Warm-Blooded Vertebrates Through Comparative Transcriptomics
- Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets
- Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia
- Circuitry and plasticity of the dorsal horn--toward a better understanding of neuropathic pain.
- A 3.7 kb Fragment of the Mouse Scn10a Gene Promoter Directs Neural Crest But Not Placodal Lineage EGFP Expression in a Transgenic Animal
- Substratum preferences of motor and sensory neurons in postnatal and adult rats
- Trp channels and itch
- Cellular Deconstruction: Finding Meaning in Individual Cell Variation
- The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
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