New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?
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Summary
Chronic itch and chronic pain share many similar mechanisms, including peripheral sensitization (increased responses of primary sensory neurons to itch and pain mediators), central sensitized (hyperactivity of spinal projection neurons and excitatory interneurons), loss of inhibitory control in the spinal cord, and neuro-immune and Neuro-glial interactions.
- Type
- review
- Published
- 2013-05-01
- Cited by
- 179
- References
- 165
- Access
- Open access
- OpenAlex
- https://openalex.org/W1988631520
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14374301
Keywords
Neuroscience, Sensory system, Spinal cord, TRPV1, Medicine
References
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- Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch
- A subpopulation of nociceptors specifically linked to itch
- NC/Nga Mice: A Mouse Model for Atopic Dermatitis
- Cerebral representation of the relief of itch by scratching.
Cited by
- Lysophosphatidic acid‐induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1
- GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way.
- Insights into Bombesin receptors and ligands: highlighting recent advances
- Itch control by Toll-like receptors.
- NK-1 Antagonists and Itch.
- The role of PPAR-gamma receptor in pruritus.
- Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms?
- Research in practice: Substance P antagonism in chronic pruritus
- S-777469, a Novel Cannabinoid Type 2 Receptor Agonist, Suppresses Itch-Associated Scratching Behavior in Rodents through Inhibition of Itch Signal Transmission
- Forschen für die Praxis: Substanz‐P‐Antagonisierung bei chronischem Pruritus
- Mast cells: versatile gatekeepers of pain
- The spinal inhibition of N-type voltage-gated calcium channels selectively prevents scratching behavior in mice.
- A putative antipruritic mechanism of the phosphodiesterase‐4 inhibitor E6005 by attenuating capsaicin‐induced depolarization of C‐fibre nerves
- Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1
- Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
- A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief
- Burden of itch in epidermolysis bullosa
- Diversification and specialization of touch receptors in skin.
- A Sensory Neuron-expressed Interleukin-31 Receptor Mediates T helper Cell-dependent Itch: Involvement of TRPV1 and TRPA1
- TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch
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