Identification of a cold receptor reveals a general role for TRP channels in thermosensation
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Summary
These findings, together with the previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
- Type
- article
- Published
- 2002-03-07
- Cited by
- 2,589
- References
- 50
- OpenAlex
- https://openalex.org/W1995330222
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4340358
Keywords
TRPM8, Transient receptor potential channel, Thermoreceptor, Neuroscience, Menthol
References
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Cited by
- Structure-function relationship of the TRP channel superfamily.
- The non-selective monovalent cationic channels TRPM4 and TRPM5.
- Role of the transcription factor DRG11 in the embryonic development of the nociceptive system
- Oral irritation by mustard oil: self-desensitization and cross-desensitization with capsaicin.
- Paclitaxel Prevents Loss of Pulmonary Endothelial Barrier Integrity During Cold Preservation
- EGF suppresses hydrogen peroxide induced Ca2+ influx by inhibiting L-type channel activity in cultured human corneal endothelial cells.
- Thermosensitivity of the two‐pore domain K+ channels TREK‐2 and TRAAK
- Molecular mechanisms of trigeminal nociception and sensation of pungency.
- Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions.
- Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement.
- TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.
- Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.
- Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats.
- TRP channels and pain.
- Attenuated cold sensitivity in TRPM8 null mice.
- Cold sensitivity of recombinant TRPA1 channels.
- Principios de aromaterapia científica y aplicaciones prácticas en podología
- Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation
- Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice.
- Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice
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