Glutamate decarboxylase antibody levels predict rate of beta-cell decline in adult-onset diabetes.
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Summary
Not only did G AD65Ab presence predict future insulin dependence, but higher GAD65Ab levels may mark more rapid decline in beta-cell function in apparent non-insulin-dependent diabetes.
- Type
- article
- Published
- 1995-02-01
- Cited by
- 62
- References
- 21
- OpenAlex
- https://openalex.org/W2032747194
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25517164
Keywords
Medicine, Diabetes mellitus, Glutamate decarboxylase, Internal medicine, Antibody
References
- Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
- Antibodies to Glutamic Acid Decarboxylase Reveal Latent Autoimmune Diabetes Mellitus in Adults With a Non—Insulin-Dependent Onset of Disease
- Immunogenetic and Clinical Characterization of Slowly Progressive IDDM
- Pancreatic Islet-cell Antibodies in Diabetes Mellitus Correlated with the Duration and Type of Diabetes, Coexistent Autoimmune Disease, and HLA Type
- 64,000 Mr autoantibodies as predictors of insulin-dependent diabetes.
- Persistence of Serum Antibodies to 64,000-Mr Islet Cell Protein After Onset of Type 1 Diabetes
- Islet Cell and Thyrogastric Antibodies in 633 Consecutive 15- to 34-Yr-Old Patients in the Diabetes Incidence Study in Sweden
- Correlation Between Residual β-Cell Function and Islet Cell Antibodies in Newly Diagnosed Type I Diabetes: Follow-Up Study
- A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes.
- Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes.
- Islet-cell antibodies and endogenous insulin secretion in Sudanese diabetic children.
- Antibodies to Glutamic Acid Decarboxylase Discriminate Major Types of Diabetes Mellitus
- Pancreatic beta-cell function evaluated by intravenous glucose and glucagon stimulation. A comparison between insulin and C-peptide to measure insulin secretion.
- Insulin antibodies in insulin-dependent diabetics before insulin treatment.
- Measurement of hemoglobin A1c by a new liquid-chromatographic assay: methodology, clinical utility, and relation to glucose tolerance evaluated.
- Recombinant Glutamic Acid Decarboxylase (Representing the Single Isoform Expressed in Human Islets) Detects IDDM-Associated 64,000-Mr Autoantibodies
- Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus
- Quantitative Assay Using Recombinant Human Islet Glutamic Acid Decarboxylase (GAD65) Shows That 64K Autoantibody Positivity at Onset Predicts Diabetes Type
Cited by
- Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus – a nationwide study
- Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15–34 years) but not in middle-aged (40–59 years) diabetic patients
- Weight loss and nausea in a patient taking digoxin
- Insulin Treatment in Type 2 Diabetes
- Bipolar Disorder: not only in the Brain - immunological aspects
- Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr
- Exploring the Grey Zone between Type 1 and Type 2 Diabetes
- Evaluation of a novel radioimmunoassay using125I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies
- Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA).
- The clinical characteristics of latent autoimmune diabetes in adults and its relation with chronic complications in metabolically poor controlled Turkish patients with Type 2 diabetes mellitus.
- Anti‐GAD65 autoantibody in Taiwanese patients with insulin‐dependent diabetes mellitus: effect of HLA on anti‐GAD65 positivity and clinical characteristics
- Clinical and metabolic characteristics of patients with latent autoimmune diabetes in adults (LADA): absence of rapid beta-cell loss in patients with tight metabolic control.
- Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?
- Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
- Islet cell autoantibody levels after the diagnosis of young adult diabetic patients
- Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring.
- Reduced endogenous insulin secretion in diabetic patients with low-titer positive antibodies against GAD
- Influence of age on clinical and immunological characteristics of newly diagnosed type 1 diabetic patients
- What are the characteristics of phenotypic type 2 diabetic patients with low-titer GAD65 antibodies?
- Latent autoimmune diabetes in adults (LADA): usefulness of anti-GAD antibody titers and benefit of early insulinization.
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