Antibodies to Glutamic Acid Decarboxylase Discriminate Major Types of Diabetes Mellitus
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Summary
A simple laboratory test with a defined autoantigen has substantial implications for population screening and early diagnosis of IDDM and for better understanding of its pathogenesis.
- Type
- article
- Published
- 1992-04-01
- Cited by
- 200
- References
- 23
- OpenAlex
- https://openalex.org/W2048304876
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17594118
Keywords
Glutamate decarboxylase, Diabetes mellitus, Islet, Antibody, Autoantibody
References
- Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
- Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase
- Primary biliary cirrhosis: paradigm or paradox for autoimmunity.
- Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein
- L-Glutamate decarboxylase from brain.
- GABA and pancreatic beta‐cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic‐like microvesicles suggests their role in GABA storage and secretion.
- Predicting type I diabetes.
- Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10.
- Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases
- Characterization of a cDNA coding for rat glutamic acid decarboxylase.
- A RAPID METHOD FOR ASSAYING ENZYMES WHOSE SUBSTRATES AND PRODUCTS DIFFER BY CHARGE. APPLICATION TO BRAIN l‐GLUTAMATE DECARBOXYLASE
- Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies.
- Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets.
- Monoclonal antibodies to glutamic acid decarboxylase.
- Insulin antibodies in insulin-dependent diabetics before insulin treatment.
- Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
- Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.
- Molecular targets in pernicious anaemia.
- Initial Pathogenic Events in IDDM
- Diabetes
Cited by
- The Low Prevalence of Immunogenetic Markers in Korean Adult-Onset IDDM Patients
- Single test for two hereditary neuropathies, CMT1A and HNPP.
- Latent Autoimmune Diabetes in Adults (LADA)
- Calcium- and Proteasome-dependent Degradation of the JNK Scaffold Protein Islet-brain 1*
- Problems in differential diagnosis of diabetes types.
- HLA-DRB1 Alleles Contribute to Determining the Prognosis of Japanese Diabetes Mellitus Positive for Antibodies to Glutamate Decarboxylase
- Diabetic cardiomyopathy: effects of fatty acids and glucose on adult rat cardiac cells
- Endocrine Autoimmunity and Associated Conditions
- 精製ラット脳GAD (グルタミン酸脱炭酸酵素) 及びGAD合成ペプチドを用いたドットプロット法による抗GAD抗体測定-基礎的検討-
- Association between immune reactivity and disease status of type 1, type 2 diabetes and latent autoimmune diabetes in adults
- The role of synaptogenic synaptic adhesion molecules in insulin secretion
- Longitudinal changes in epitope recognition of autoantibodies against glutamate decarboxylase 65 (GAD65Ab) in prediabetic adults developing diabetes
- Epidemiological studies of childhood onset type 1 diabetes in Devon and Cornwall
- Diabetes mellitus, Thyroid dysfunction, FBS, HbA1c, T3, T4, TSH.
- Clinical features and differential diagnosis of type 2 diabetes mellitus in children
- Antibodies to Glutamic Acid Decarboxylase in Australian Children with Insulin-Dependent Diabetes Mellitus and Their First-Degree Relatives
- Autoantibodies against GAD65 rather than GAD67 precede the onset of type 1 diabetes.
- Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes.
- Evaluation of ICA512As in Combination With Other Islet Cell Autoantibodies at the Onset of IDDM
- HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients.
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