A Map of Recent Positive Selection in the Human Genome
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Summary
A set of SNPs is developed that can be used to tag the strongest ∼250 signals of recent selection in each population, and it is found that by some measures the authors' strongest signals of selection are from the Yoruba population.
- Type
- article
- Published
- 2006-03-01
- Cited by
- 2,896
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2025253353
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1800819
Keywords
Biology, International HapMap Project, Selection (genetic algorithm), Single-nucleotide polymorphism, Genetics
References
- Human Evolutionary Genetics
- Initial sequence of the chimpanzee genome and comparison with the human genome
- Inferences about human demography based on multilocus analyses of noncoding sequences.
- Haplotype test reveals departure from neutrality in a segment of the white gene of Drosophila melanogaster.
- Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data.
- A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees
- A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome
- Human Evolutionary Genetics: Origins, Peoples and Disease.
- Linkage disequilibrium in the human genome
- Microsatellite variation and evolution of human lactase persistence
- Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes.
- Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation.
- Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes
- Genomic regions exhibiting positive selection identified from dense genotype data.
- Complex signatures of natural selection at the Duffy blood group locus.
- Natural selection on the olfactory receptor gene family in humans and chimpanzees.
- Evidence for substantial fine-scale variation in recombination rates across the human genome
- Detecting recent positive selection in the human genome from haplotype structure
- A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size
- Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens
Cited by
- Evolutionary accounts of human behavioural diversity
- Genetics of flystrike, dagginess and associated traits in New Zealand dual-purpose sheep : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, New Zealand
- Identifying genes underlying skin pigmentation differences among human populations
- Leptin Receptor Genotype at Gln223Arg is Associated With Body Composition, BMD, and Vertebral Fracture in Postmenopausal Danish Women
- HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombination.
- A genome-wide scan for signatures of recent selection in Holstein cattle.
- Genomic Differentiation Between Temperate and Tropical Australian Populations of Drosophila melanogaster
- Integration of genetic and immunological insights into a model of celiac disease pathogenesis.
- Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
- No Evidence for Strong Recent Positive Selection Favoring the 7 Repeat Allele of VNTR in the DRD4 Gene
- Positive Selection on the Osteoarthritis-Risk and Decreased-Height Associated Variants at the GDF5 Gene in East Asians
- Purifying Selection Causes Widespread Distortions of Genealogical Structure on the Human X Chromosome
- Distinct Patterns of Genetic Variations in Potential Functional Elements in Long Noncoding RNAs
- Detecting natural selection in genomic data.
- Low Frequency Variants, Collapsed Based on Biological Knowledge, Uncover Complexity of Population Stratification in 1000 Genomes Project Data
- Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals
- Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies
- Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers
- Common polymorphisms in WNT10A affect tooth morphology as well as hair shape.
- Using genome-wide measures of coancestry to maintain diversity and fitness in endangered and domestic pig populations
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