Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
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Summary
In vivo findings suggest that IDE hypofunction may underlie or contribute to some forms of AD and DM2 and provide a mechanism for the recently recognized association among hyperinsulinemia, diabetes, and AD.
- Type
- article
- Published
- 2003-03-12
- Cited by
- 1,352
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W2076517751
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20623657
Keywords
Insulin-degrading enzyme, Hyperinsulinemia, Biology, Endocrinology, Insulin
References
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- Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells
- The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
- The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.
- Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.
- High-Level Neuronal Expression of Aβ1–42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
- Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
- Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells.
- Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)*
- Insulin-degrading enzyme: embarking on amyloid destruction.
- Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling.
- Risk of dementia among persons with diabetes mellitus: a population-based cohort study.
- Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.
- Alzheimer's Disease β-Amyloid Peptide Is Increased in Mice Deficient in Endothelin-converting Enzyme*
- Advanced glycation end products contribute to amyloidosis in Alzheimer disease.
- Neutral endopeptidase modulation of septic shock
- Longitudinal association of vascular and Alzheimer’s dementias, diabetes, and glucose tolerance
- The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner*
- Diabetes mellitus and the risk of dementia
Cited by
- Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
- The Genetics of Alzheimer’s Disease
- Aβ aggregation and possible implications in Alzheimer's disease pathogenesis
- Insulin is a Two-Edged Knife on the Brain
- Promoting α‐secretase cleavage of beta‐amyloid with engineered proteolytic antibody fragments
- Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation.
- Effects of glucose and insulin on secretion of amyloid‐β by human adipose tissue cells
- Stem Cell Therapy for Alzheimer’s Disease: A Review of Recent Clinical Trials
- Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer’s Disease
- GLP-1 receptor regulates cell growth through regulating IDE expression level in Aβ1–42-treated PC12 cells
- Cellular and proteolytic studies of Alzheimer's disease amyloid beta peptide with microglia, stem cells and MMP9
- Hyperinsulinemia is associated with increasing insulin secretion but not with decreasing insulin clearance in an age‐related metabolic dysfunction mice model
- Cachexia and advanced dementia
- Saccades in Alzheimer’s disease: an MRI study.
- Carnosine and its possible roles in nutrition and health.
- Differential Localization of Hic-5 and Paxillin in the Brain of Alzheimer's Disease Subjects
- Could Carnosine or Related Structures Suppress Alzheimer's Disease?
- Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-β Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer’s Disease
- The Role of Peroxisome Proliferator-Activated Receptor-γ PPARγ) in Alzheimer’s Disease
- Potential Blood Biological Markers of Alzheimer's Disease
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- BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE)*♦
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